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ARTICLE
Year : 1985  |  Volume : 5  |  Issue : 2  |  Page : 86-90

Svarna-Vanga -A short duration toxicity study


1 Dept. of Rasa Shastra, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India
2 Dept. of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India
3 Dept. of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India

Correspondence Address:
Sharma
Dept. of Rasa Shastra, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005
India
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Source of Support: None, Conflict of Interest: None


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Swarna - Vanga, an Ayurvedic preparation, is used in the treatment mainly of Pramehas (genitor urinary and metabolic disorders), Sveta Pradara (Leucorrhoea), Kasa - Swasa (Respiratory disorders), etc. The drug contains tin and sulphur as major components along with traces of mercury, iron and aluminum. According to modern point of view certain metals have been claimed toxic to both human and animal. Since Svarna - Vanga contains these metals, it is essential to screen out its toxic effect, if any, although it is claimed in Ayurveda that when a metal is processed as prescribed, it become non - toxic or the least toxic. Considering the above facts, an animal experiment was carried out for short duration (14 days) to screen the toxic effects of Svarna - Vanga (SV) in increasing doses of the drug starting from the maximum therapeutic dose (12.5 mg / 100 gm b.wt / day). The drug was found to have no toxic effects in tissues of the animal at doses of 12.5 mg and 25 mg / 100 gm b.wt. / day. Fine fatty vacuolization in liver and focal superficial mucosal degeneration and necrosis of small intestine confined to one animal each at dose of 50 mg / 100gm b.wt. and 100 mg/ 100 gm. b.wt. / day were observed. Our study indicates that the drug has no toxic effect on tissues at therapeutic dose.


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