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ARTICLE
Year : 1985  |  Volume : 5  |  Issue : 2  |  Page : 91-97

Effect of nimbidin on gastric acid secretion


1 C. D. R. S. Pharmacological Unit, Dept. of Pharmacology Medical College, Trivandrum - 695 011, India
2 Jt. Director of Medical Education Trivandrum - 695 011, India

Correspondence Address:
N R Pillai
C. D. R. S. Pharmacological Unit, Dept. of Pharmacology Medical College, Trivandrum - 695 011
India
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Source of Support: None, Conflict of Interest: None


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Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti - secretory activity in pylorus ligated rats and cats. In lumen - perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA - induced back - diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 - receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man.


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