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ARTICLE
Year : 1987  |  Volume : 7  |  Issue : 1  |  Page : 30-38

'Antiandrogenic properties of Neem seed oil (Azadirachta indica) in male rat and rabbi'


Reproductive Physiology Unit, Department of Zooloogy, University of Rajasthan, Jaipur - 302 004, India

Correspondence Address:
J D Sharma
Reproductive Physiology Unit, Department of Zooloogy, University of Rajasthan, Jaipur - 302 004
India
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Source of Support: None, Conflict of Interest: None


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Azadirachta indica (Neem) seed oil brings about a significant diminution in spermatozoan motility and density. It leads to reduction of fertility rate in rats and rabbits. The body weight of the animals remain unaffected but the weights of reproductive oranges declined. Reduction of cauda epididymal protein, sialic acid, acid phosphatase and seminal vesicular fructose concentration in rats and rabbits could bedue to antiandrogenic action of the seed oil as confirmed with the help of bioassay techniques. Histopathology of testis revealed arrest of spermatogenesis and sever degenerative changes in the cauda epididymis.


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