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ARTICLE
Year : 1994  |  Volume : 14  |  Issue : 1  |  Page : 71-76

Protective effect of fraction of Azadirachta indica leaf extract on Carbon Tetrachloride induced hepatotoxicity


Department of Pharmaceutics Technology, Jadavpur University, Calcutta - 700 032, India

Correspondence Address:
Pulok Mukherjee
Department of Pharmaceutics Technology, Jadavpur University, Calcutta - 700 032
India
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Source of Support: None, Conflict of Interest: None


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The hepatoprotective activity of a fraction of the leaf extract of A.indica against carbon tetrachloride : liquid paraffin (1:1) induced liver damage in rats at doses of 100 mg/kg and 200 mg/kg was evaluated. A significant dose dependent hepatoprotective activity was evidenced by lowering of the elevated levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) in the serum of CCl 4  : liquid paraffin (1:1) treated rats.


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