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ARTICLE
Year : 1995  |  Volume : 15  |  Issue : 2  |  Page : 137-139

An in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds


Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001, India

Correspondence Address:
Y.S.R. Reddy
Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001
India
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Source of Support: None, Conflict of Interest: None


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In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2­substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3­(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans.


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