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ARTICLE
Year : 1998  |  Volume : 18  |  Issue : 1  |  Page : 52-57

Pharmacological investigations on Aglaia roxburghiana (w. &.a) Miq. Var. beddomei leaves


1 Department of pharmacology, sri ramachandra medical college & research institute, (Deemed University), Porur, Chennai 600 116, Tamil Nadu, India
2 Institute of pharmacology, Chennai medical college, Chennai 600 003, India
3 Captain Srinivasa Murti drug research institute for Ayurveda, Arumbakkam, Chennai 600 106, India

Correspondence Address:
S Janaki
Department of pharmacology, sri ramachandra medical college & research institute, (Deemed University), Porur, Chennai 600 116, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


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Aglaia roxburghiana  is a traditional remedy for a variety of diseases. The ethanolic extract of the leaves was screened for related activities were upon it exhibited significant anti-inflammatory activity in rats in acute and chronic models. There was no acute toxicity in mice upto 2g/kg. The extract protected the mast cell deregulation by compound 48/80 and inhibited histamine induced contractions in guinea pig ileum. The data obtained in this study suggest that the extract ma act by stabilizing mast cells ad blocking histamine receptors.


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