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ARTICLE
Year : 2002  |  Volume : 22  |  Issue : 1  |  Page : 17-27

Evaluation of analgesic, anticonvulsant locomotor activities of alcoholic extract achyranthes bidentata blume in mice


1 Adhiparashthi college of pharmacy, Melmaruvathur-603 319, India
2 Department of siddha medicine, faculty of sciences, Tamil University, Thanjavur, India

Correspondence Address:
T Vetrichelvan
Adhiparashthi college of pharmacy, Melmaruvathur-603 319
India
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Source of Support: None, Conflict of Interest: None


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The alcoholic extract of Achyranthes bidentata (AAB) has been studied for analgesic, anticonvulsant and CNS depressant activities in animal models. Analgesic activity was studied using acetic acid-induced writing test for assessing peripheral analgesic effect and tail immersion test for central analgesic effect. Anticonvulsant activity was performed by maximal electroshock induced convulsions; while the locomotor activity was evaluated using actophotometer. AAB (250-500 mg/kg) significantly reduced the number of wriths induced by acetic acid and elevated pain threshold in hot water test. The extract (500mg/kg) exhibited anticonvulsant activity significantly (P<0.001) against tonic seizures induced by MES. The results of locomotor activity showed the significant (P<0.01) CNS depressant effect at the three doses (250,375 and mg/kg) employed. The results suggest that AAB exhibited analgesic, anticonvulsant and CNS depressant activity in a dose dependent pattern.


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