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ARTICLE
Year : 2011  |  Volume : 31  |  Issue : 1  |  Page : 3-9

Biopotency of Acalypha indica Linn on Membrane Bound ATPases and Marker Enzymes urolithic Rats


1 Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore, India
2 Department of Chemistry, V.P.M.M. Arts and Science College for Women, Krishnankoil, India

Correspondence Address:
M Sathya
Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore
India
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Source of Support: None, Conflict of Interest: None


PMID: 22736883

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The ethanolic extract of Acalypha indica was tested for its biopotency on membrane bound enzymes and marker enzymes in urolithiasis in male wistar albino rats. Calcium oxalate urolithiasis was induced by 0.75% ethylene glycol in drinking water for 30 days. There was a significant decrease in membrane bound enzymes such as Ca 2+ ATPase, Mg 2+ ATPase, Na + K + ATPase and marker enzymes Aspartate Transaminase (AST), Alanine Transaminase (ALT), Acid phosphatase (ACP) and Alkaline Phosphatase (ALP) in liver and kidney. The AST, ALT, ACP and ALP were increased in serum and urine of rats. Therapeutic treatment with plant extract (200mg/kg b.wt.dose -1 day -1 oral -1 ) has significantly ameliorated to near normalcy in the curative group. These results of the present study concluded that A. indica can play an important role in the prevention of disorders associated with kidney stone formation .


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