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ORIGINAL ARTICLE
Year : 2012  |  Volume : 32  |  Issue : 1  |  Page : 11-15

Study of Brāhmī Ghṛta and piracetam in amnesia


1 Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
2 Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, India

Correspondence Address:
K. R. C. Reddy
Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0257-7941.113791

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Objective: To compare the effect of Brāhmī Ghta with piracetam (a reference standard chemical) in amnesia. Materials and Methods: Brāhmī Ghta contained Brāhmī (Bacopa monneri), Vacā (Acorus calamus), Kuṣṭha (Sassurea lappa), Śakhapupī (Convolvulos pluricalis), and Purāa Ghta, prepared as per snehapāka process. Antiamnesic activity of Brāhmī Ghta (400 and 800 mg/kg, p.o.) was evaluated in scopolamine (1 mg/kg, s.c.) induced amnesia in Charles Foster rats using elevated plus maze, passive avoidance, and active avoidance tests. Piracetam (500 mg/kg, p.o.) was used as standard drug. This effect was compared with standard chemical used in experimental study. Results: Brāhmī Ghta - (in both doses) and piracetam-treated rats significantly reversed the effect of scopolamine in modified elevated plus maze, passive avoidance, and active avoidance tests. But there were no significant differences observed in antiamnesic activity of Brāhmī Ghta and standard drug. Conclusion: Brāhmī Ghta and piracetam produced significant beneficial effect on scopolamine-induced amnesic effect, but no significant difference was observed in between them.


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