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REVIEW ARTICLE
Year : 2012  |  Volume : 32  |  Issue : 1  |  Page : 3-10

Botanical identity of plant sources of Daśamūla drugs through an analysis of published literature


Centre For Pharmacognosy, Pharmaceutics, Pharmacology, Centre For Ism Informatics, Institute of Ayurveda and Integrative Medicine (Foundation for Revitalization of Local Health Traditions), Banglaore, Karnataka, India

Date of Web Publication21-Jun-2013

Correspondence Address:
Padma Venkatasubramanian
Director, Institute of Ayurveda and Integrative Medicine, Foundation for Revitalization of Local Health Traditions, No. 74/2, Jarakabande Kaval, Post Attur, via Yelahanka, Bangalore - 560 106, Karnataka
India
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Source of Support: National Medicinal Plants Board, New Delhi, Conflict of Interest: None


DOI: 10.4103/0257-7941.113790

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  Abstract 

Background: Daśamūla (DM) is a top-traded group of medicinal plants used by the Ayurvedic industry. Through literature survey and analysis, this article has enlisted the botanical sources of DM, as correlated by several scholars. Such a list is not available from any single, earlier publication. It brings to light the confusion that exists in terms of botanical sources correlated to Ayurvedic entities. There is quite a bit of difference in the botanical correlation, parts, and substitutes reported in the different scholarly works, particularly for Pṛṣṇiparī, and Agnimantha. For e.g., is Uraria picta the original intended Pṛṣṇiparī, as the Ayurvedic Formulary of India (AFI) stipulates or is it U. lagopoidiodes or Desmodium gangeticum as other scholars report? While AFI provides two botanical correlations to Agnimantha in its two editions, namely Premna integrifolia and Clerodendrum phlomidis, other scholars correlate it to other Premna and Clerodendrum species. Why has AFI provided stem bark and whole plant as substitutes for roots of DM? Are substitutes recommended by AFI only for ecological or practical convenience or is there an Ayurvedic or pharmacological explanation for the same?
Aim: There are many species used in the name of Daśamūla,, in this article all the species are listed out to find the differences in the usage of the drugs.
Materials and Methods: Ayurveda texts and lexicons along with the texts which have done correlation work were considered to arrive at a list of various species used as Dasmula.
Results and Conclusion: Since neither the methodology nor the logic behind the correlation have been discussed in these scholarly works, including the AFI, the same is not available for analysis or scrutiny. Such a list as provided in this article can form an essential base for a much needed systematic approach at etymological analysis, botanical correlation, and further scientific work to establish legitimacy of substitutes prescribed.

Keywords: Ayurveda, botanical name correlation, Daśamūla, medicinal plants, substitutes


How to cite this article:
Aparna S, Ved DK, Lalitha S, Venkatasubramanian P. Botanical identity of plant sources of Daśamūla drugs through an analysis of published literature. Ancient Sci Life 2012;32:3-10

How to cite this URL:
Aparna S, Ved DK, Lalitha S, Venkatasubramanian P. Botanical identity of plant sources of Daśamūla drugs through an analysis of published literature. Ancient Sci Life [serial online] 2012 [cited 2019 Apr 19];32:3-10. Available from: http://www.ancientscienceoflife.org/text.asp?2012/32/1/3/113790


  Introduction Top


Daśamūla literally means 'ten-roots'. The 10 plant drugs of Daśamūla (DM) are grouped as Bhatpañcamūla (roots of five tree species) and Laghupañcamūla (roots of five shrubs or herbs). The Bṛhatpañcamūla are Bilva, Agnimantha, Śyonāka, Pāalā, and Gabhārī while Laghupañcamūla include Pṛṣṇiparī, Śālaparī, Bhatī, Kaṇṭakāri, and Gokura. It is estimated that more than 10,000 M. tonnes of plant raw drugs belonging to DM group is being consumed every year by Indian herbal industry contributing to nearly ~Rs. 500 crore (~USD 1 billion) turnover through the sale of herbal formulations containing this group of medicinal plants.[1]

DM plants are the major ingredients of top-selling Ayurvedic products such as Daśamūlarishta, Daśamūla Kaśāya, and Daśamūlakautrayādi Kvāyam. Caraka has mentioned the components of Daśamūla under the śvayathuhara gaṇa i.e. the group of 10 drugs that combat oedema[2] and uses the word Mahat Pañcamūla and Daśamūla in several contexts. Suśruta gives a classification as Bṛhatpañcamūla and Laghupañcamūla in the classification of drugs.[3] The Ayurvedic texts have mentioned that DM plant drugs mainly pacify vāta dośa.[3] Currently, the official Ayurvedic Formularies of India (AFI) have listed the ingredients of DM, their Ayurvedic/Sanskrit names, and the correlated botanical sources.[4],[5],[6]

Even though the exact methodology adopted to identify botanical sources for Ayurvedic drugs has not been published, it has been mentioned briefly by Bapalal Vaidya[7] and Balwant Singh and Chunekar[8] that it was done through etymological analysis of drug synonyms as given in classical texts and by interviewing traditional practitioners and Ayurvedic scholars. This required the active engagement of scholarship in Sanskrit, Ayurvedic practice, and plant taxonomy. Several scholars have correlated DM with different botanical entities including some regional variants or substitutes. It is important for the industry as well as researchers to be aware of both the authentic as well as other botanical entities used as equivalents, for two reasons. Firstly, to develop critical pharmacognostic standards to distinguish the former from the latter, for the purpose of quality control and secondly to study the legitimacy of such substitution, i.e. their equivalence in terms of the bioactivities. Proactively identifying legitimate substitutes for authentic but unavailable plant drugs is the need of the hour for the Ayurvedic industry and for that a proper awareness about variation in the usage of different botanical identities is the first step.


  Materials and Methods Top


In order to compile the information available on the botanical sources of Daśamūla group of plant drugs a detailed literature review was carried out on selected classical and current day texts on Ayurveda and trade of plant drugs as provided in [Table 1], including the official Ayurvedic pharmacopoeias published by the Government of India. The basis of selection of these texts is that they are primary references on botanical nomenclature correlation work of Ayurvedic plants and not just a mere report on traded plants and botanical entities. The DM species and their substitutes as mentioned in AFIs have been summarized in [Table 2]. Information from other texts regarding the authentic plant sources, their substitutes and the parts used has been incorporated in [Table 3] [36],[37],[38]. For the current study, the plant species mentioned in the official pharmacopoeias of Ayurveda have been considered as authentic and legitimate substitutes.
Table 1:

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Table 2:

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Table 3:

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NB: The period of original Ayurvedic manuscripts [[Table 1]: No 7 and 8] is provided in parenthesis as per the published work “The History of Ayurveda”.[9]


  Results and Discussion Top


The literature analysis indicated that the botanical entities and parts correlated as DM varied between scholarly works [Table 2] and [Table 3]. Confusion has also crept in because some authors have treated taxonomic synonyms of the same plant species as different botanical entities while a few have clubbed different species as one. Many authors have merely correlated the DM herbs to botanical entities but not mentioned the part to be used [Table 3]. This may be because it is implied that Daśamūla refers to roots.

We have firstly discussed the findings on the botanical entities and substitutes as provided in three different editions of AFI [Table 2] and in other works [Table 3]. Subsequently we have also discussed the reports on the parts to be used.

Botanical entities correlated as DM and their substitutes as reported in different scholarly works

Bilva, Śyonāka, and Gabhārī

There is no controversy regarding the botanical correlation of Bilva, Śyonāka, and Gabhārī. All scholars have correlated Aegle marmelos Corr. (Rutaceae) as the source of Bilva, Oroxylum indicum Vent. (Bignoniaceae) as Śyonāka and Gmelina arborea Linn. (Verbenaceae) as Gabhārī. There is no mention of substitute plant source for Bilva by any of the authors [Table 2] and [Table 3]. Bapalal Vaidya has listed Ailanthus excelsa Roxb. as a substitute for Śyonāka.[7] Kolammal mentions Gmelina asiatica Linn. as a substitute for Gabhārī[10] while Trewia nudiflora Linn. (Euphorbiaceae) has been provided as a substitute for Gabhārī by Bapalal Vaidya[7] Chunekar on the other hand has provided both Premna flavescens Ham. (Verbenaceae) as well as Trewia nudiflora Linn. as substitutes for Gabhārī.[11]

Agnimantha

There is an inherent difference within the three AFIs published with regard to the botanical sources of Agnimantha [Table 2]. The first edition (Part I) mentions Clerodendrum phlomidis Linn.f as the authentic botanical source and Premna integrifolia Linn. as well as Premna mucronata Roxb. as substitutes.[4] However, in the second edition of Part I, Premna integrifolia has been mentioned as the authentic plant source and C. phlomidis as well as P. mucronata are provided as the substitutes.[5] In Part II of the first edition of AFI on the other hand, C. phlomidis. Linn.f. has been listed as the authentic Agnimantha and Premna obtusifolia R. Br as well as Premna mucronata Roxb. are listed as the substitutes [Table 2].[6] The basis for this variation in listing of botanical sources for Agnimantha is not provided and hence not clear.

Several authors have correlated Agnimantha to Clerodendrum phlomidis Linn.f [Table 3]. Kolammal correlates Agnimantha Premna serratifolia Linn. and Premna latifolia Roxb. as substitute.[10] Warrier and Sivarajan correlate Agnimantha to Premna corymbosa Rottl.[12],[13] The texts and lexicons of Ayurveda mention two varieties of Agnimantha, namely Bṛhat Agnimantha (big variety) and Laghu Agnimantha or Kṣudra Agnimantha (small variety) which have been correlated to Premna integrifolia and Clerodendrum phlomidis respectively by the scholars [Table 3].[7],[11] Sharma (2006) mentions two varieties of Agnimantha as Agnimantha (bigger variety) correlated to Premna mucronata Roxb and Tarkārī (smaller variety) as Clerodendrum phlomidis.[14] Premna serratifolia Linn. and Premna spinosa Roxb. are the other species correlated to Agnimantha. Both these botanical names are treated as synonyms of Premna integrifolia Linn. by plant taxonomists. Premna latifolia Roxb.Var. mucronata C.B. Clarke (a botanical synonym of Premna mucronata Roxb.) has also been considered by some authors as Agnimantha.[8],[15],[16] According to Nadkarni, as well as Kamat and Mahajan Clerodendrum inerme (L.) Gaertn is a source of Agnimantha.[17],[18]

No substitute species is mentioned for any of the 10 candidates of DM except for Agnimantha in AFI [Table 2].

alā

For example in the case of the plant drug alā, Stereospermum suaveolens (L.f.) DC., and Stereospermum chelonoides (L.f.) DC of Bignoniaceae are botanical synonyms but have been mentioned as different species by Kamat and Mahajan[17] [Table 3]. Kolammal correlates Stereospermum tetragonum DC. (Syn. Stereospermum chelonoides C.B. Clarke) as alā, and Radermachera xylocarpa (Syn. Stereospermum xylocarpum Benth and Hook) as another kind of alā called Ghaṇṭāpāalā or ṣṭhapāalā,[10] Warrier correlates Stereospermum colais (Dillwyn) Mabb as alā.[19] Stereospermum chelonoides has been considered as ṣṭhapāalā by Kamat and Mahajan.[17] Similarly some entities that are not synonymous have been clubbed together as synonymous e.g. Stereospermum chelonoides and Stereospermum colais (Dillwyn) Mabb are distinct species but have not been distinguished by Sastry[20] [Table 3]. Stereospermum tetragonum DC. which is actually a botanical synonym of Stereospermum colais (Dillwyn) Mabb, has been listed as another source of alā,.[21]

Bhatī and Kaṇṭakāri

Bhatī and Kaṇṭakāri, are referred as Bhatī Dvaya. They have similar properties as per Ayurveda in terms of Rasa (taste) and Gua (properties) and textual references indicate that they are used together.[20] AFI correlates Bhatī to Solanum indicum Linn. (syn. Solanum anguivi Lam.) and Kaṇṭakāri, to Solanum xanthocarpum Schard and Wendle (syn. Solanum virginianum L.), both of Solanaceae. Most of the scholars have agreed with this correlation as can be seen in [Table 3]. However, a few scholars from southern India have included Solanum melongena Linn. also as the source of Bhatī [Table 3].[13] Eventhough AFI mentions no substitutes for Bhatī and Kaṇṭakāri, Sharma (2006) and Singh (1999) have said Solanum incanum Linn., Solanum torvum Swartz., and Solanum melongena Linn. as substitutes.[8],[14]

Śālaparī and Pṛṣṇiparī

The text of Caraka mentions Catasra Parī which includes Śālaparī and Pṛṣṇiparī,[22] They are used together and one is also used in the place of the other in some parts of the country. Both are different plant species belonging to the same family (Fabaceae) as correlated in the API. The controversy regarding Pṛṣṇiparī, and Śālaparī, is region based. Uraria picta Desv. is the authentic plant source of Pṛṣṇiparī, as per API, but U. lagopodioides DC. is also being used by the industry due to unavailability of U. picta in the required volumes.[1] However, AFI recognizes no substitute for Pṛṣṇiparī.[4],[5],[6] In Kerala, Desmodium gangeticum (L.) DC., which is known as Śālaparī, in API, is used as Pṛṣṇiparī, while Pseudrathria viscida is used as Śālaparī.[13] According to Warrier Pseudrathria viscida is Śālaparī, and Desmodium gangeticum is Pṛṣṇiparī,[12],[23] So, in all, there are at least four candidates, namely U. picta Desv., U. lagopodioides DC., D. gangeticum (L.) DC., and P. viscida Wight and Arn that are in use as Pṛṣṇiparī.

Gokura

Gokura is correlated to Tribulus terrestris Linn. by all the scholars. Pedalium murex Linn. is considered as Bhatī Gokura (bigger variety) by some authors.[8],[11],[12],[14],[20] Bapalal Vaidya considers Pedalium murex Linn., Xanthium strumarium L., and Martynia daindra Glox. are the other species used as Gokura.[7]

Plant parts reported for Daśamūla

The main observation from [Table 2] is that there is a variation in the listing of plant parts used between the Part I (editions I and II) and Part II of AFI. In the first edition, only roots are listed as plant drugs for all the 10 plant entities constituting DM group.[4] In the second edition of Part I, stem bark for Bhatī pañcamūla and whole plant for Laghu pañcamūla have been listed in addition to the roots, under the formulations containing DM, such as Daśamūlāriṣṭam, Daśamūlaharītakī Leha, and Daśamūla Kvātha Cūrnam.[5] Part II of AFI reverts to roots being the only plant part to be used, under the formulations of Bṛhacchagalyādya ghṛtam and Daśamūla Taila.[6] Thus, the use of stem bark has been mentioned as substitute for roots of Bhatī pañcamūla and whole plant as substitute for the Laghu pañcamūla only in the second edition of AFI Part I[5] and not in AFI Part I edition I nor in AFI Part II.[4],[6]

The Ayurvedic Pharmacopeias of India (API) dealing with single ingredients have mentioned roots of Bhatī pañcamūla and whole plant of Laghu pañcamūla as the plant parts to be used for DM.[24],[25],[26],[27] On the other hand the API on formulations lists the roots or stem bark of Bhatī pañcamūla and whole plant of Laghu pañcamūla as parts to be used.[28],[29] API (formulations) in the context of Daśamūla ghta has considered has Premna integrifolia as official substitute for Clerodendrum phlomidis and considered stem bark and whole plant as the parts used.[28] In the context of Daśamūlaharītakī Leha root/stem bark and whole plant of the drugs has been taken into consideration.[29]

The main question in this regard is that the basis of why stem bark or whole plants have been listed as substitutes for roots is not clear or elaborated in the AFI or API.

Classical Ayurveda texts around 16th century AD such as Yogaratnākara have indicated the use of substitute drugs (Pratinidhi Dravya) in the absence of original drugs (Abhāva Dravya) e.g., Musta (Cyperus rotundus) has been suggested as a substitute for Ativiśa (Aconitum heterophyllum).[30],[31]

A few references can also be found regarding substituting with alternative parts of the same plant when the intended parts are not practical to be harvested. For e.g., when flowers of Bilva (Aegle marmelos) are unavailable, use of unripe fruits has been suggested in Bhaiajya Ratnāvalī (“Puhpābhāve phalaňchāmam vibhede bilwatah phalam).[32] There is mention about the use of Śālaparī , (Desmodium gangeticum) when Pṛṣṇiparī (Uraria picta) is unavailable.[33] However, such references are few and far between, the logic is still not clear and it cannot be extrapolated as a thumb rule to all species. It requires further scientific exploration.

Future research needs to focus on not only identifying substitute species but also substitute parts that may be more available, for e.g., stem instead of roots or leaves instead of flowers, etc.

While roots are generally the part used in DM, there are a few authors who refer to other parts as well. Sastry mentions root bark as part to be used for both Śyonāka and alā [Table 3].[20]

Use of both root and whole plant for Pṛṣṇiparī and whole plant of Bhatī, Kaṇṭakāri, and Gokura has been mentioned by Bapalal Vaidya in Ādarsha Niganu.[21] Other than AFI, scholars have not listed stem bark or whole plant as substitutes for roots [Table 3]. AFI does not provide the logic as to how stem bark or whole plant as substitutes.

Our work, has, for the first time compiled and analyzed the botanical entities that have been correlated in published texts as sources of one or more of DM group of raw drugs. This has brought to light the fact that there are several species reported as DM candidates other than the ones correlated in the official AFI. Over and above these, it is also an accepted fact that the Ayurvedic industries use several more species as sources of DM raw drugs depending on the geographical region and availability of herbs. There are also issues of authentic correlation of botanical entities, legitimacy of substitution, and controversies regarding parts used as well as taxonomic synonymy that need to be resolved.[34],[35] These can only be resolved through systematic etymological analysis of Ayurvedic terms for each of the Daśamūla candidates and correlation to the accurate botanical entity with the help of competent field botanists, Sanskrit, and Ayurvedic scholars. Such studies need to be published in peer reviewed journals and provided also in the official pharmacopoeias for future reference so that the basis of correlation is clear. It is also important to research and publish the pharmacognostic standards and the comparative bioactivity of original herbs (and parts) alongside substitutes (and parts), so that the sector knows about the legitimacy of substitution.


  Conclusions Top


Through a literature analysis of several scholarly works, this article has brought out a list of botanical sources correlated as DM plants. It is clear from the list that there is quite a bit of confusion in terms of the right botanical entity, plant part or substitutes used. It has brought to light issues that need to be resolved in terms of authenticity of correlation of Ayurvedic entities to botanical sources like Pṛṣṇiparī, Śālaparëī, and Agnimantha. The need to spell out the logic behind use of substitute parts and species has also been highlighted. Such a list is made available as one publication for the first time. It will be useful for any further work on DM, be it for confirmation of botanical source or for pharmacognostic and pharmacological studies to establish quality standards or legitimacy of substitution. Since DM is a very important plant drug group for the Ayurvedic industry, further Research and Development in the above areas is warranted.


  Acknowledgment Top


Project grant received from the National Medicinal Plants Board, Government of India, is gratefully acknowledged. Our sincere thanks go to Dr. Venugopal, Dr. Ravikumar, and Dr. Subrahmanya for their inputs.

 
  References Top

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[PUBMED]  Medknow Journal  
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    Tables

  [Table 1], [Table 2], [Table 3]


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