Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Users Online: 631 | Home Print this page Email this page Small font size Default font size Increase font size
ORAL PRESENTATION
Year : 2013  |  Volume : 32  |  Issue : 6  |  Page : 13

OA02.07. Experimental evaluation of "yakritashula vinashini vatika" w.s.r. to hepatoprotective potential in albino rats.


National Institute of Ayurveda, Jaipur, Rajasthan, India

Correspondence Address:
Anita Mali
National Institute of Ayurveda, Jaipur, Rajasthan
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0257-7941.123826

Rights and Permissions

Purpose: According to the latest W.H.O. data published in April, 2011 death due to liver disease in India has reached 2.3% of total deaths. This stands 27th in the world. Till date, there is no effective medicine for treating hepatic disorders in modern medicine, so efforts have been made to search for effective Hepatoprotective drug. The purpose of the present study was to evaluate the Hepatoprotective activity of Yakritashula Vinashini Vatika (YSV) against Carbon tetrachloride induced Hepatotoxicity in rats. Method: The toxicant CCl4 was used to induce Hepatotoxicity at a dose of (1 ml/kg b. w.) as 1:1 mixture with olive oil. YSV was administered in the dose of (200 and 400 mg/kg .b .w. /day) orally for 28 days. And the results were compared with known standard drug Silymarin (100mg/kg b. w.). The Hepatoprotective effect of YSV was evaluated by the assessment of biochemical parameters such as SGOT, SGPT ALP, Total Billirubin, Serum Protein, Lipid profile. Result: The toxic effect of CCl4 was controlled in the animals treated with the YSV by way of restoration of level of liver function biochemistry similar to that of the standard drug Silymarin. Among the YSV treated groups significant Hepatoprotective activity was observed. In the histopathological studies, the liver sections of rats treated with YSV 200 & 400 mg/kg respectively, a normal hepatic architecture was seen with only moderate accumulation of fatty lobules and mild degree of cell necrosis, clearly indicating the protection offered by drug. Conclusion: From the results it can be concluded that YSV possesses Hepatoprotective effect against CCl4 induced liver damage in rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1175    
    Printed26    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal