Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Users Online: 113 | Home Print this page Email this page Small font size Default font size Increase font size


 
 Table of Contents  
POSTER PRESENTATION
Year : 2013  |  Volume : 32  |  Issue : 6  |  Page : 75

PA03.06. Swertiamarin A novel lead to antidepressants


PSG College of Arts and Science, Coimbatore, India

Date of Web Publication4-Jan-2014

Correspondence Address:
K Dharaniyambigai
PSG College of Arts and Science, Coimbatore
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0257-7941.123898

Rights and Permissions
  Abstract 

Purpose:
Conventional medicine says depression is a psychological disorder due to imbalance of neurotransmitters in the brain and that which thereby focuses on managing depression rather than curing it. Contrary, ayurveda treats depression in a gentle, natural and effective way. Identification of ligands and phytochemicals that are responsible for antidepressant activity in plants are necessary in order to develop efficient drugs that are rapid and effective naturally without side effects even in acute administration.
Method:
Swertiamarin an unique phytochemical of the Gentianaceae family is a secoiridoid glucoside, is purified and quantified from sources namely Enicostemma littorale, Swertia chirata, S.japonica and S.angustifolia using HPLC with ethyl acetate: methanol: water (7.7:2.0:0.5) solvent systems. This purified phytochemical, hypothesized to possess antidepressant activity is then subjected to structure elucidation using mass spectrophotometer and Xray diffraction studies and proceeded with homology modeling for docking the swertiamarin with imipramine, citalopram, fluoxetine and venlafaxine receptors (antidepressant sites). The purified swertiamarin is further subjected to clinical and biochemical parameter analysis thereby analysing its potential to treat the depression induced in animals (group study) comparison with the standard allopathic antidepressants.
Result:
The source rich in swertiamarin can be determined using HPLC and are considered for further clinical and therapeutic parameters. The comparative structure elucidation of swertiamarin with MS and Xray diffraction analysis from various sources under study can predict the diversity of the compound which can serve as basis for functional analysis. The modeling and docking studies reveal the interactions of swertiamarin with its receptors (site of action) whose understanding can aid in revealing its mechanism as an antidepressant. Besides these, the clinical trials in shows the efficiency of swertiamarin as an antidepressant when compared to other drugs.
Conclusion:
This study can provide basis for improvement of ayurvedic antidepressants through phytochemical and clinical research which can aid gentler and quick treatment that can result from low and acute doses.


How to cite this article:
Dharaniyambigai K, Doss V A. PA03.06. Swertiamarin A novel lead to antidepressants. Ancient Sci Life 2013;32, Suppl S1:75

How to cite this URL:
Dharaniyambigai K, Doss V A. PA03.06. Swertiamarin A novel lead to antidepressants. Ancient Sci Life [serial online] 2013 [cited 2019 Jul 19];32, Suppl S1:75. Available from: http://www.ancientscienceoflife.org/text.asp?2013/32/6/75/123898

From the proceedings of Insight Ayurveda 2013, Coimbatore. 24th and 25th May 2013






 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract

 Article Access Statistics
    Viewed634    
    Printed24    
    Emailed0    
    PDF Downloaded72    
    Comments [Add]    

Recommend this journal