Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Users Online: 27 | Home Print this page Email this page Small font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2015  |  Volume : 34  |  Issue : 3  |  Page : 126-129

Nephroprotective activity of Bilvādi agada in gentamicin induced nephrotoxicity in male Wistar rats


1 Department of Agadatantra, KLEU's Shri B.M.K. Ayurveda Mahavidyalaya, Shahapur, Karna, India
2 Department of Pharmacology and Toxicology, KLE College of Pharmacy, Belgaum, Karnataka, India

Correspondence Address:
Dr. Sangeeta Kanna
Department of Agadatantra, KLEU's Shri B.M.K. Ayurveda Mahavidyalaya, Shahapur, Belgaum, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0257-7941.157146

Rights and Permissions

Background: Gentamicin (GM) nephrotoxicity accounts for 10-30% of the acute renal failure (ARF) among drug-induced ARF. In Ayurveda such side effects are considered as the poisonous effects of low potent poisons called gara viṣa. Bilvādi agada (BA), a classical formulation is indicated in gara viṣa and most of its ingredients have proven for their nephroprotective activity. Aim: The aim was to evaluate the effect of BA in GM-induced nephrotoxicity in male Wistar rats. Materials and Methods: BA, GM, normal saline were procured from standard companies. Settings and Designs: Eighteen male Wistar rats were randomly divided into three groups, viz. Control group which received normal saline intraperitoneal (i.p.) daily for 8 days; toxic group received GM 80 mg/kg/day i.p. for 8 days, and trial group received both GM 80 mg/kg/day i.p. and BA 216 mg/each rat weighing ~200 g orally 1 h after administration of GM. Statistics: All the values were expressed as mean ± standard error and data were analyzed by applying one-way analysis of variance followed by Dunnett's test for multiple comparison. Results: BA treated group showed a significant change (P < 0.05) in levels of serum creatinine, urine creatinine, and urine potassium. There was no significant change (P > 0.05) seen in serum potassium, sodium, chloride, calcium and phosphorus and urine sodium, chloride in all three groups. Glomerular congestion, interstitial edema, tubular necrosis, interstitial hemorrhage was reduced in BA treated group. The results of this study indicate that BA reduces GM-induced nephrotoxicity and it may be due to anti-inflammatory, immunomodulatory, diuretic and anti-oxidant properties of drugs. Further studies are necessary to explore the exact mechanism of BA in nephroprotection.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2751    
    Printed43    
    Emailed0    
    PDF Downloaded156    
    Comments [Add]    
    Cited by others 2    

Recommend this journal