Ancient Science of Life

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 31  |  Issue : 3  |  Page : 84--89

Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats


Devender O Sachdev1, Devesh D Gosavi2, Kartik J Salwe3 
1 Department of Pharmacology, Government Medical College, Jagdalpur, India
2 Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, India
3 Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, Puducherry, India

Correspondence Address:
Devesh D Gosavi
Department of Pharmacology, MGIMS, Sewagram
India

The effect of Gomutra ark (GoA) on experimental alloxan-induced diabetes in rats was studied. For this purpose, Wistar albino rats of either sex weighing 200-250 g were used. The biochemical parameters like blood sugar, vitamin C, and malondialdehyde release were measured. The safety profile of GoA was evaluated using acute and chronic toxicity studies. GoA significantly lowers blood glucose in diabetic rats although the observed effect was found to be less than glibenclamide. It significantly lowers the level of malondialdehyde and vitamin C in diabetic rats. No toxicity was observed even when cow urine was given 32 times of the study dose in acute toxicity and no significant changes were seen when it was used chronically, which suggests that cow urine is having a very high therapeutic index. This study supports the traditional use of GoA in diabetes and is having a high therapeutic index and is safe for chronic use. However, further studies are needed to elucidate the mechanism of action of Gomutra ark.


How to cite this article:
Sachdev DO, Gosavi DD, Salwe KJ. Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats.Ancient Sci Life 2012;31:84-89


How to cite this URL:
Sachdev DO, Gosavi DD, Salwe KJ. Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats. Ancient Sci Life [serial online] 2012 [cited 2019 Jun 25 ];31:84-89
Available from: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2012;volume=31;issue=3;spage=84;epage=89;aulast=Sachdev;type=0