Year : 2012 | Volume
: 32 | Issue : 5 | Page : 65-
PA01.16.Effect of sheetaprabha tablets on ethylene glycol induced urolithiasis in rats
Sampath Kumar Vemula, Nilakash A Selkar, Mukesh B Chawda, Kapil S Thakur, Mahesh K Vahalia
Shree Dhootapapeshwar Ayurvedic Research Foundation, Panvel, Navi Mumbai-410206, India
Purpose: Sheetaprabha tablets, Ayurvedic proprietary medicine, contain Sweta Parpati & Hajrul hahood bhasma as active ingredients. Sweta parpati is mainly indicated in mootravaha srotovikara & hajrul hahood bhasma is having mootrala and ashmari bhedana actions. A survey of the literature showed that no pharmacology study was made on the sweta parpati and sheetaprabha tablets. In the present study we investigated the effect of Sheetaprabha tablets in ethylene glycol induced urolithiasis in rats.
Method: Urolithiasis was induced in male wistar rats by adding ethylene glycol (0.75%) in drinking water. Protective (130mg/kg & 260mg/kg) and curative effect (130mg/kg & 260mg/kg) of Sheetaprabha was studied in experimental animal models.
Result: Ethylene glycol induced urolithiatic rats showed significant increase in blood urea nitrogen (P<0.001), creatinine & phosphorus (P<0.05) and also significant increase in SGOT, SGPT & ALP levels in serum, which were prevented by Sheetaprabha treated rats in protective groups and decreased in curative groups. Histopathologies of kidneys were prevented calcium oxalate formation and tubular degeneration, and increase in tubular regeneration was observed in protective (130mg/kg, 260mg/kg) group.
Conclusion: The present study findings indicate that treatment with Sheetaprabha tablets, which decreases and also prevents the growth of the calcium oxalate crystals in urinary tract. It also seems that the preventive effect is more effective than its curative effect. Hence, this study confirms the traditional use of Sheetaprabha tablets in urolithiasis.
Sampath Kumar Vemula
Shree Dhootapapeshwar Ayurvedic Research Foundation, Panvel, Navi Mumbai-410206
|How to cite this article:|
Vemula SK, Selkar NA, Chawda MB, Thakur KS, Vahalia MK. PA01.16.Effect of sheetaprabha tablets on ethylene glycol induced urolithiasis in rats.Ancient Sci Life 2012;32:65-65
|How to cite this URL:|
Vemula SK, Selkar NA, Chawda MB, Thakur KS, Vahalia MK. PA01.16.Effect of sheetaprabha tablets on ethylene glycol induced urolithiasis in rats. Ancient Sci Life [serial online] 2012 [cited 2020 Jul 9 ];32:65-65
Available from: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2012;volume=32;issue=5;spage=65;epage=65;aulast=Vemula;type=0