Ancient Science of Life

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 33  |  Issue : 2  |  Page : 109--113

In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus


Javad Sharifi Rad1, Seyedeh Mahsan Hoseini Alfatemi2, Majid Sharifi Rad3, Marcello Iriti4 
1 Zabol Medicinal Plants Research Center; Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
2 Department of Bacteriology and Virology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Range and Watershed Management, Faculty of Natural Resources, University of Zabol, Zabol, Iran
4 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133, Milan, Italy

Correspondence Address:
Seyedeh Mahsan Hoseini Alfatemi
Department of Bacteriology and Virology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

Background and Aims: The excessive and repeated use of antibiotics in medicine has led to the development of antibiotic-resistant microbial strains, including Staphylococcus aureus whose emergence of antibiotic-resistant strains has reduced the number of antibiotics available to treat clinical infections caused by this bacterium. In this study, antioxidant and antimicrobial activities of methanolic extract of Xanthium strumarium L. leaves were evaluated on methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) spp. Materials and Methods: Antiradical and antioxidant activities X. strumarium L. leaf extract were evaluated based on its ability to scavenge the synthetic 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and by the paired diene method, respectively, whereas the antimicrobial activity was assayed by the disc diffusion method. Statistical Analysis: Data were subjected to analysis of variance following an entirely random design to determine the least significant difference at P < 0.05 using SPSS v. 11.5. Results and Conclusions: The IC 50 values of the extract were 0.02 mg/mL and 0.09 mg/mL for the antioxidant and DPPH-scavenging capacity, respectively. X. strumarium extract affected both methicillin-sensitive Staphylococcus aureus and MRSA, though antibacterial activity was more effective on methicillin-susceptible S. aureus spp. The antibacterial and antioxidant activities exhibited by the methanol extract may justify the traditional use of this plant as a folk remedy worldwide.


How to cite this article:
Rad JS, Alfatemi SH, Rad MS, Iriti M. In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus.Ancient Sci Life 2013;33:109-113


How to cite this URL:
Rad JS, Alfatemi SH, Rad MS, Iriti M. In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Ancient Sci Life [serial online] 2013 [cited 2019 Dec 7 ];33:109-113
Available from: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2013;volume=33;issue=2;spage=109;epage=113;aulast=Rad;type=0