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ARTICLE
Year : 1995  |  Volume : 14  |  Issue : 4  |  Page : 212-224

Multicentric, placebo-controlled, randomised double-blind evaluation of a new herbal cream in Vagial infections


Department of Clinical Pharmacology & Therapeutics. The Nizam's Institute of Medical Sciences, Hyderabad - 500 482, India

Correspondence Address:
P Usha Rani
Department of Clinical Pharmacology & Therapeutics. The Nizam's Institute of Medical Sciences, Hyderabad - 500 482
India
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Source of Support: None, Conflict of Interest: None


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Efficacyand safety of a new herbal cream containing aqueous extracts of Azadirachta indica, Curcuma longa, Pongamia glabra, Glycyrrihiza glabra and Santallum album were evaluated in amulticentric, randomized, double-blind, placebo-controlled study. With active drug treatment, there was significant improvement in various signs like redness, oedema and symptoms like itching, burning, discharge and discomfort, compared to placebo treatment. Microscopic examination of smear and culture showed significant reduction of offending organisms after treatment with active drug. In patient's global evaluation, active drug was rated 70% as very good and in investigators evaluation 82% as very effective and effective. The overall efficacy was as high as 76% with active drug as against only 24% with placebo. Both active drug and placebo were well tolerated.


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