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ARTICLE
Year : 1999  |  Volume : 18  |  Issue : 3  |  Page : 205-209

Gastro intestinal effects of Croton tiglium in experimental animals


C.D.R.S. Pharmacological Unit, Medical college, Trivandrum - 695 011, India

Correspondence Address:
N R Pillai
C.D.R.S. Pharmacological Unit, Medical college, Trivandrum - 695 011
India
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Source of Support: None, Conflict of Interest: None


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Croton tiglium used as a cathartic in Ayurvedic system of indigenous medicine, was investigated for its effects in experimental animals. 50% EtOH extract of the dried nuts of the plant was used of the study. The extract exhibited a dose dependent cathartic effect in albino rats, the extract also showed an increase to gut movement with an increased contractile movement on rabbit jejunum, partially blocked by atropine these preliminary findings suggest tat the ethanol extract of the croton dried nuts elicit a purgative effect by increasing the gut motility, partially via muscarnic receptor activation.


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