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ARTICLE
Year : 2009  |  Volume : 28  |  Issue : 3  |  Page : 11-13

Diuretic activity of root Extracts of Dalbergia spinosa Roxb


1 Assistant Professor, Division of Pharmacognosy-R&D Laboratory, Department of Pharmacy, IIMT College of Medical Sciences, Meerut, India
2 Assistant Professor and Head, Department of Pharmaceutical Chemistry, Periyar College of Pharmaceutical Sciences for Girls, Trichy, India
3 Principal, Periyar College of Pharmaceutical Sciences for Girls, Trichy, India

Correspondence Address:
K P Jaiganesh
Assistant Professor, Division of Pharmacognosy-R&D Laboratory, Department of Pharmacy, IIMT College of Medical Sciences, Meerut
India
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Source of Support: None, Conflict of Interest: None


PMID: 22557314

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The benzene, alcoholic and aqueous root extracts (75mg/kg each)of Dalbergia  spinosa Roxb were studied for its diuretic activity by using male albino rats by adopting the method of Tipschitz. The alcoholic extract increased the urine volume and electrolytes sodium, potassium and chloride, which is similar to the standard drug Furosemide (100mg/ kg) by inhibiting sodium, potassium, and chloride ion co-transport at thick ascending loop of henle. The present study showed that the alcoholic extract has significant diuretic activity comparable with standard drug Furosemide in producing urinary output and excretion of sodium,potassium and chloride in mEq/ lit/ 6 hrs


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