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ARTICLE
Year : 2010  |  Volume : 29  |  Issue : 4  |  Page : 29-34

Effect of ethanolic fruit extract of pedalium murex Linn. in ethylene glycol induced urolithiasis in male wistar albino rats


1 Research scholar, Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore, India
2 Associate professor and Head, Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore, India
3 Lecturer, Department of Biochemistry, Dr. N. G. P. College of Arts and Science, Coimbatore, India

Correspondence Address:
K S Ananta Teepa
Research scholar, Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore
India
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Source of Support: None, Conflict of Interest: None


PMID: 22557365

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The ethanolic fruit extract of Pedalium murex to ethylene glycol intoxicated rats reverted the levels of the liver and kidney markers to near normal levels protecting liver and renal tissues from damage and also prevents the crystal retention in tissues. The levels of ACP, ALP, AST, ALT in serum andurine were significantly increased due to the damaged structural integrity of renal and hepatic cells causing the enzymes which are located in the cytoplasm to be released into the circulation. The levels of ACP and ALP, AST, ALT in renal and hepatic tissues of ethylene glycol induced rats might be due to leakage of the enzyme into the general circulation from the collateral circulation. LDH levels in serum, urine and tissues were increased on ethylene glycol intoxication is due to the oxalate induced renal and hepatic cellular damage.


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