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ARTICLE
Year : 2011  |  Volume : 30  |  Issue : 3  |  Page : 72-77

Prevention of acetaminophen induced hepatorenal damage in mice with rhizomes of Glycyrrhiza glabra A histophysiological study


School of Studies in Zoology and Biotechnology, Vikram University, Ujjain 456010, India

Correspondence Address:
H S Rathore
School of Studies in Zoology and Biotechnology, Vikram University, Ujjain 456010
India
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Source of Support: None, Conflict of Interest: None


PMID: 22557431

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Protective role of Gycyrrhiza glabra rhizomes (roots) at three dose levels (100, 75, & 50 mg/kg/bw) against sublethaldose (300 mg/kg/bw) of acetaminophen (paracetamol) induced hepatorenal damage has been assessed in mice. Parameters of study were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), billirubin, alkaline phosphatase (ALP) as liver function tests, creatinine and urea as kidney function tests and histology for pathology. G.glabra could antagonize acetaminophen induced both,hepato and nephrotoxicity in dose dependent manner. No protection provided by a single dose of G.glabra (1.5 gm/kg/bw) against lethal dose of acetaminophen (1gm/kg/bw). Probable protective role is discussed.


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