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ORIGINAL ARTICLE
Year : 2013  |  Volume : 33  |  Issue : 2  |  Page : 123-130

Evaluation of Brāhmī ghṛtam in children suffering from Attention Deficit Hyperactivity Disorder


1 Department of Clinical Pharmacology, TNMC and BYL Nair Ch. Hospital, Mumbai, Maharashtra, India
2 Department of Dravyaguna, Tilak Ayurved Mahavidyalaya, Pune, Maharashtra, India
3 Department of Psychiatry, TNMC and BYL Nair Ch. Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Renuka Munshi
Department of Clinical Pharmacology, TNMC and BYL Nair Ch. Hospital, Mumbai Central, Mumbai 400 008, Maharashtra
India
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Source of Support: Nair Golden Jubilee Research Foundation, TNMC & BYL Nair Ch. Hospital, Mumbai., Conflict of Interest: None


DOI: 10.4103/0257-7941.139057

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Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity. In view of the adverse effects associated with psycho-stimulants used for the treatment of this disorder, efficacy of Brāhmīghṛtam was evaluated in this condition. Materials and Methods: After following due ethical considerations, children of either sex between the age group of 6 and 12 years diagnosed to be suffering from mixed variety of ADHD as per The Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria irrespective of other co-morbid psychiatric illnesses were recruited in the study. Initially a pilot study (n = 10) was carried out to confirm the efficacy of the identified dose of Brāhmīghṛtam. Using this dose, further therapeutic confirmatory study (n = 27) was carried out, wherein Brāhmīghṛtam was compared with methylphenidate. Effect on ADHD symptoms was assessed using the Dupaul ADHD rating scale and this was the main efficacy parameter. Results: In the pilot exploratory study, Brāhmīghṛtam showed 66% decrease in total ADHD score. In the therapeutic confirmatory study, only 16% improvement was seen with Brāhmīghṛtam, which was similar to methylphenidate, standard treatment for ADHD that was used as a comparator in the present study. No side-effects were reported in both studies. Conclusion: Our study thus has adequately demonstrated efficacy and safety of Brāhmīghṛtam in ADHD.


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