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Year : 2015  |  Volume : 35  |  Issue : 2  |  Page : 85-89

Role of quassinoids as potential antimalarial agents: An in silico approach

Department of Biochemistry, Cachet Labs, Yousufguda, Hyderabad, Telangana, India

Correspondence Address:
Shailima Rampogu
Department of Biochemistry, Cachet Labs, Yousufguda, Hyderabad, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0257-7941.171676

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Background: Malaria is an infection caused by mosquitoes in human beings which can be dangerous if untreated. A well known plant product, quassinoids are known to have antimalarial activity. These bioactive phytochemicals belong to the triterpene family. Quassinoids are used in the present study to act against malarial dihydrofolate reductase (Pf-DHFR), a potential antimalarial target. Nevertheless, viṣama jvara (~malaria) has been treated with the bark of Cinchona since a long time. Aim: The aim of the present experiment is to perform the protein-ligand docking for Pf- DHFR and Quassinoids and study their binding affinities. Setting and Design: The software used for the present study is the discovery studio (Accelrys 2.1), Protein Data Bank (PDB), and Chemsketch. Materials and Methods: The protein for the present study was imported from protein data bank with the PDB Id, 4dpd and was prepared for docking. The ligands used for the study are the quassinoids. They were drawn using chemsketch and the 3D structures were generated. The docking was done subsequently. Statistical Analysis Used: Molecular modeling technique was used for the protein-ligand docking analysis. Results: The docking results showed that the Quassinoids Model_1 showed the highest dock score of 40.728. Conclusion: The present study proves the promising potential of quassinoids as novel drugs against malaria. The dock results conclude that the quassinoids can be adopted as an alternative drug against malaria.

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