Ulcer healing potential of ethanolic extract of Caralluma attenuata on experimental diabetic rats
Sunil Garg1, Sajal Srivastava2, Kisanpal Singh3, Alok Sharma4, Kavita Garg5
1 Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, India
2 Amity Institute of Pharmacy, Amity University, Lucknow Campus, Lucknow, UP, India
3 Department of Pharmacy, Dr. K. N. Modi Institute of Pharmaceutical Education, Modinagar, UP, India
4 Clinical Research Division, Synapse Clinical Research Foundation, Delhi, India
5 R and D Division, INC Research Inc., Gurgaon, Haryana, India
Amity Institute of Pharmacy, Amity University, Lucknow Campus, Lucknow - 226 028, Uttar Pradesh
Source of Support: None, Conflict of Interest: None
Introduction: Available data indicated that diabetes mellitus (DM) increases the vulnerability of the gastric ulcers and the need of the hour is to develop effective agents to treat ulcer with diabetes for better patient compliance and cost effectiveness. The ulcer-healing properties of ethanolic extract of Caralluma attenuata (CAEt) against both chemically- and physically induced gastric ulcers in experimental rats are recently studied.
Aim: To assess the ulcer healing potential of Ethanolic Extract of Caralluma attenuata on Experimental Diabetic Rats.
Material and Methods: The current study aimed to evaluate ulcer healing properties of CAEt on the aspirin induced gastric ulcer in rats with streptozotocin induced DM. The hypothesis is based on the fact that DM results in compromising the mucosal defensive factors associated with delay in gastric ulcer healing, and if these changes can be corrected by using agents known for their antidiabetic and antiulcer properties. Experimental albino rats were divided into six groups. Except for Group I, other groups contained streptozotocin-induced diabetic rats. Group I (normal control) and Group II (diabetic control) were administered vehicle, Groups III and IV (diabetic experimental) were administered CAEt in dose of 100 mg/kg and 250 mg/kg, respectively, and Groups V and VI (positive controls) were respectively administered oral standard drugs omeprazole, 20 mg/kg, and tolbutamide 10 mg/kg.
Result: The results confirmed that the CAEt significantly decreases the ulcer index (P < 0.05) in the aspirin-induced gastric ulcers and also significantly exhibit antioxidant and glucose lowering activity in the diabetic ulcer rats. The study showed that C. attenuata has the potential to be used as an antiulcer agent in experimental diabetic rats.