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  Citation statistics : Table of Contents
   2013| January  | Volume 32 | Issue 6  
    Online since January 4, 2014

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OA03.11. A comparative study of guggulu chitrak kshar ‑ sutra and snuhi apamarg kshar ‑ sutra in the management of fistula in ano
Pushpa Gond, Ashok Kumar, PN Rajeshwari, PC Choudhary, Jitendra Kumar
January 2013, 32(6):34-34
Purpose: Fistula in ano is a condition which has been recognized as difficult surgical diseases in all the ancient and modern medical sciences of the world. In Ayurvedic texts fistulainano is described as Bhagandar. This disease is recurrent in nature which makes it more difficult for treatment. So it produces inconvenience in routine life. KsharSutra has been proved as a big revolution in the treatment of fistulainano. It is the need to do further researches to get more efficient Kshar Sutra. Method: The present study was clinical, randomised, single blind trial.In the present research work Guggulu Chitraka KsharSutra has been taken for comparative study wth snuhi apamarga ksharsutra.Thirty patients cases of fistulainano were selected from OPD/IPD of Shalya Tantra department of National Institute of Ayurveda, Jaipur. Total patients were divided into two equal groups.The patients of group A were treated with Snuhi Apamarga KsharSutra and the patients of group B were treated with Guggulu Chitraka KsharSutra. Result: In the study the effect of Guggulu Chitraka KsharSutra was found better in pain, itching, pus discharge, tenderness and burning sensation and the rate of Unit Cutting Time was slightly higher as Snuhi Apamarga KsharSutra. Conclusion: Though U.C.T of Guggulu Chitrak Kshara Sutra is slightly higher than Snuhi Apamarga Kshar Sutra, but in assessment parameter Guggulu Chitrak Kshar Sutra has been shown significant result.With guggulu chitrak ksharsutra post ligation complications like hypertrophied scar etc are not seen and this is easily available and cost effective.
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OA03.16. Therapeutic evaluation of ayurvedic therapy on power and spasticity in children effected with cerebral palsy
Kishor Gavali, Shrinidhi Kumar
January 2013, 32(6):39-39
Purpose: Cerebral palsy is the most familiar physical disability in childhood, occurring in 2.0 to 2.5 per 1000 live birth, yet in numerous cases the cause remains unknown. It is a problem for Ayurvedic physicians to diagnose and treat such a big ailment on Ayurvedic lines due to nonavailability of clinical entity named as Cerebral Palsy in Ayurvedic classics but indirect references are surely scattered in various chapters. Therefore, considering it as challengeable melody, present study has been undertaken to find out an effective and safer medication as well as panchkarma procedures in Ayurveda to improve power and spasticity in children affected with cerebral Palsy by evaluating the therapeutic effects of combined Ayurvedic therapy including Samwardhana Ghrita, Hapushadi Yapan Basti, Abhyanga, Shashtika Shali Pinda Sweda and Physiotherapy and comparing it with the therapeutic effects produced by Physiotherapy alone. Method: Clinical study was performed on 28 children, clinically evaluated with CP of age group 1 12 yrs, selected randomly from OPD/IPD of Balroga department of N.I.A., Jaipur which were then categorized into two groups. 14 Patients of Group A were treated with Physiotherapy alone and 14 patients of Group B were treated with combination of Hapushadi Yapan basti, Abhyanga, Shashtika Shali Pinda Sweda Samwardhana Ghrita and Physiotherepy. Result: The study reveals that patients in group B showed more improvement on Spasticity which is statistically very significant over group A. On power, group B is more efficacious than group A from percentage change and result significance but did not show any significant advantage over group A when analyzed statistically. Conclusion: Combined Ayurvedic therapy with physiotherapy can be used efficiently in the management of spasticity and power in children affected with Cerebral Palsy.
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PA01.04. Clinical study of shvadmstradi kwatha in the management of mutra ashmari (urinary calculi)
Mohammed Thameem
January 2013, 32(6):45-45
Purpose: Renal calculi are the second most common disease of the urinary tract. Ashmari is a disease in which there is formation of stone, resulting into severe pain as given by enemy. It occurs commonly in the Mutravahasrotas. The symptoms like pain abdomen, burning Micturation, heamturia. Objectives of the present study were to get a solution to Mutra Ashmari by evaluating the efficacy of Shvadmstradi Kvatha. Method: 30 patients fulfilling the inclusion criteria of Mutra Ashmari were randomly selected from the opd and ipd of S.D.M College of Ayurveda & hospital, Hassan. Shvadmstradi Kvatha was given with 50ml bd before food for 21 days follow up was done for the period of 2 months. Clinical sign and symptoms were given on the basis of self formulated scoring scale. The result having p value less than <0.05 were considered as statistically significant in this study. Result: Overall effect of therapies after the course of treatment showed based on signs & symptoms. Pain abdomen 83.95 %, frequency of micturition 43.28 %, burning micturition 100 %, haematuria 100 % no of calculi 30.0 %, size of calculus 49.91%, descent of calculi 44.77%. Conclusion: Shvadmstradi Kvatha has significant effect in the management of Mutra Ashmari. Reduction in clinical symptoms was appreciated after internally administration of medicine which is proved statistically significant.
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PA03.17. A clinical evaluation of Punarnavadi Mandura and Dadimadi Ghritha in management of pandu (Iron defeciency anaemia)
Ambika Das, S Saritha
January 2013, 32(6):86-86
Purpose: Iron deficiency anaemia is currently the most micronutrient deficiency affecting 1.5 billion people globally. in our country 50% of children are Anemic.the features of iron deficiency anaemia are almost similar with that of Panduroga mentioned in Ayurvedic classics.Punarnavadi mandura and Dadimadi Ghrita are mentioned in the management of Pandu.Mandura (Fe2O3) directly increases serum ferritin,Punarnava decreases gastric irritation produced by Mandura,while Dadimadi Ghrita helps for better digestion and absorption.Hence,the study was planned to find the efficacy of these drugs in Pandu. Method: The present study was conducted on 50 children fulfilling inclusion criteria in between the age group of 10 to 14 years. The patients were selected from S.D.M.C.A & Hospital, Hassan. Punarnavadi Mandura 500 mg B.D and dadimadi Ghritha 10 ml B.D with luke warm water for a period of 84 days( 3 lunar months) The cases were recorded according to the case proforma prepared for the study and observations were recorded. Result: Symptoms were statistically analyzed before and after treatment, their was statistically significant changes (P < 0.001) were observed in the signs and symptoms of Pandu rogi(IDA). There was a statistically significant response in hemoglobin and other hematological investigation like MCHC,MCV,PCV,Reticulocyte Count ,peripheral Blood smear,serum iron,serum Ferritin and Total Iron Bindinig Capacity in the Group (P < 0.001). Conclusion: Punarnavadi Mandura and Dadimadi Ghrita are effective in the management of Pandu roga( Iron Deficiency Anemia).
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OA02.03. Healers in the context of culture: The ashtavaidya tradition of Kerala, South India.
PU Leela
January 2013, 32(6):9-9
Purpose: The present paper provides a comprehensive and dynamic profile of Ashtavaidya system of medicine existing in Kerala. It discussed about a traditional group of Vaidyas (specifically Ashtavaidyas) who have inextricable influence on the sociocultural location of traditional healing practices in Kerala. The Ashtavaidyas are the Kerala Brahmin (Namboothiri) practitioners who are specialized in the eight branches of the Ayurveda. Their system of medicine is based on Vagbhata's Ashtangahridyam. Method: The study has relied both on primary and secondary resources for data collection. The primary mode of data gathered through personal interviews. Unstructured interviews used for this purpose. As an interviewer, the researcher collected data from the senior Ashtavaidyas of Kerala. In the first phase, the field work was conducted with Ashtavaidya families of pazhanellippurathu Thaikkattu and Elayidath Thaikkattu situated in Thrissur and Chirattamann Illam and Olassa moss in Kottayam district. The second phase of the field work was with Vaidyamadham and Pulamanthol Illam in the northern part of Kerala. Palm leaves and family histories also constitute the primary resources for the study. The secondary sources include books, journals, articles, unpublished materials. Result: The sociological significance of this study alludes to the way in which the Ashtavaidya tradition sailed through the myriad historical and cultural conjectures. It also informs us about the internal dynamics and differential social location within a normatively given community which produces both an 'elevated' space of priesthood and Vaidyas. Conclusion: Cultural factors play a critically important role in health. Social conditions and situations not only promote the possibility of illness and disability, but they also enhance prospects for disease prevention and health maintenance. Individuals and societies tend to respond to health problems in a manner consistent with their culture, norms and values.
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OA02.02. Phytochemical constituents and antioxidative property of Musa acuminata flower as green corrosion inhibitor of mild steel in acid media
N Gunavathy
January 2013, 32(6):8-8
Purpose: Corrosion is a major problem that must be confronted for safety, environmental and economic reasons. Organic compounds used as corrosion inhibitors are expensive, toxic and non biodegradable. The present investigation deals with the aim of finding eco friendly and cost effective natural inhibitor. The adsorption characteristic of phytochemical of Musa acuminata 'nendran' flower [MAN (F)] was studied to assess the mechanism of corrosion inhibition. Method: The inhibitive effect MAN (F) extracts in 1 N HCl, 1 N H2SO4 and 1 N H3PO4 on mild steel was evaluated using conventional weight loss, electrochemical potentiodynamic polarization, AC impedance techniques and SEM analysis. Result: The inhibitor efficiency of MAN (F) extracts increases with an increase in concentration but decreased with temperature. The potentiodynamic polarization curves reveal that MAN (F) acts as a mixed type inhibitor and adsorption of extract follows Temkin adsorption. Surface studies SEM confirmed the efficiency of the flower extract as corrosion inhibitor. The flower extract was an excellent corrosion inhibitor for mild steel showing a maximum efficiency of 97.16%, 95.01% and 70.03 % in 1N HCl, H2SO4 and H3PO4 respectively at 5 hours in 2 % v/v extract. Conclusion: In traditional medicine of India and the ancient Persia this Golden fruit called the 'fruit of wise' is regarded as nature's secret of perpetual youth. Musa acuminata 'nendran' (AAB) is good source of vitamins, potassium, magnesium, phosphorus, calcium and iron. All parts of the banana plant have medicinal applications. The flowers are used in treatment of bronchitis, constipation, ulcers, diabetic, reduce painful and excess menstrual bleeding and enhance milk supply in lactating mothers. The phytochemical components of Musa acuminata flower like tannins, flavonoids, saponin, alkaloid and phenols are found to be responsible for inhibiting corrosion. The natural flavonoids present in the flower extract exhibit anti-oxidative activity that stop oxidation and hence corrosion.
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OA01.06. A successful clinical case study of Asthenozoospermia + Oligozoospermia
Raghavendra Nadargi
January 2013, 32(6):6-6
Purpose: To enlighten hidden treasure of Ayurvedic treatment principles in present scenario diseases. Method: A male patient of 26 yrs age, came for treatment of Male infertility since three years. Obese, wt.100 kg, Kapha Pitta Prakruti, normal secondary sex characters, No any past history of major medical illness, No any habits, occupation - textile factory manager. Semen exam revealed Oligospermia (low sperm count) and Asthenozoospermia (Zero sperm motility). Thorough clinical examination and literature review discovered this condition as Shukragat Vaat Kshaya. He received sequential medications as Shukragat Vaat Chikitsa, Shukra Stroto Shodhana Chikitsa, Upadansha Chikitsa, Vajikaran Chikitsa, Kaphaj Paandu Chikitsa, Sthoulya Chikitsa. Result: Total duration of treatment was 16 months. Initial sperm count was 6 mill/ml, 100 % Non motile sperms. After treatment count was 58 mill/ ml, 85 % motile sperms. Being sperm count increased and motility was excellent forward progressive, 'Garbhadhan' occurred 4 months back. Conclusion: Ayurvedic Siddhantas are key to Clinical success. Mere Shukra Vardhan Chikitsa is not crucial regarding treatment of Asthenozoospermia, rather one has to think about other factors like Paandu, Upadansh, Shukragat Vaat Chikitsa, Avaran Chikitsa, Sthoulya Chikitsa.
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OA02.01. Fibroblast growth inhibitory and antiinflammatory effect of Curcumin extract: A cell culture study
K Bhuvaneswari, M Ramanathan, Prathap Balaji
January 2013, 32(6):7-7
Purpose: Curcumin is an active principle obtained from the plant curcuma longa which is not a new therapeutic tool but proved long time back with lots of medicinal values in traditional medicine . This dried rhizome powder extract had been studied extensively in animal models and proved with antiinflammatory activity . Many human studies had proved its antiinflammatory action and its effectiveness in reducing inflammation in osteoarthritis and its benefits in rheumatoid arthritis. Because this extract widely used for anti-inflammatory action in arthritis and help in healing a wound we had planned to compare the effectiveness with known antiinflammatory agent methyl prednesolone. Method: Curcumin extract, fibroblast cells L6 rat skeletal muscle cell line ( NCCS, Pune), Medium DMEM (Dulbecco's Modified Eagles Medium) with 10% fetal bovine serum in 5% CO2 at 37°C, Drug Prednisolone and Curcumin successive extract. Curcumin extract: Locally available Curcumin rhizomes was purchased after confirmation with botanical survey department of India, Coimbatore, allowed drying at shade for three to four months after cleaning with water to remove the mud and dust. After three months Rhizomes were powdered. This powdered cumin were used to prepare successive extract as per the standard technique using chloroform and ethanol with the help of Soxhlet apparatus for cell culture study with the varying doses of 100μg, 300μg, 600μg, 900μg and 1200μg using MIT Assay. Result: After 24hrs of the drug treatment, the medium was changed for all the groups and 10 μl of MTT (5 mg/ml stock solution) was added and the plates were incubated for an additional 4 hrs. The medium was discarded and the formazan blue, which was formed in the cells, was dissolved with 50 μl of DMSO. The optical density was measured at 570 nm. The percentage toxicity was calculated & IC 50 was calculated by using Grapad PRISM software tool following formula. Conclusion: Curcumin extract has role in chronic inflammation based on the inhibitory role on connective tissue cell fibroblast proliferation when compared with the known established anti-inflammatory agent methyl prednisolone.
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OA01.04. Ayurvedic management of chronic rheumatoid arthritis with severe deformities - A case report
RM Sujithra
January 2013, 32(6):4-4
Purpose: Female 62 yrs clinically diagnosed rheumatoid arthritis at the age of 12. Both wrists are affected, evident swan neck deformity, completely eroded knee joints, and a large venous ulcer on the left ankle. Patient is immobile and is on a wheel chair. She screams with pain even on the mildest touch. Dressing for ulcer was stopped because it was not healing. She was on out patient medication for 6 months, inpatient treatment for 35 days and follow up op treatments. The clinical and symptomatic evaluation depicted a remarkable improvement post Ayurvedic treatment. Method: The patient had the first consultation in March 2012. The medicines were changed on April 12th, May 4th, 25th, June 25th, and July 3rd. The internal medicines were Dhanvantaram kashaya, kokilakshaka kashayam, chyavanaprasham, and sukumara lehyam. She took inpatient treatment in julyaugust for 35 days including abhyangam, dhara pizhichil, and kshira vasti. The follow up op treatment continued until december 2012. The patient is being followed up regularly and reports no untoward symptoms. Result: Blood parameters CRP 5.24mg/dl (22/3/12), 21.5mg/l (18/7/12), 0.47mg/dl (16/8/12), RA 640IU/ml (22/3/12), 610 IU/ml (18/7/12), 317 IU/ml (16/8/12), HB 10g/dl (22/3/12), 9.5g/dl (18/7/12), 9.1 g/dl (1/8/12), 9.4 g/dl (16/8/12), Symptoms The pain has reduced. Venous ulcer completely healed. Stopped taking pain killers except when there is unbearable pain. Able to move around and do her daily chores except without much strain. Conclusion: Even in a chronic case of rheumatoid arthritis that was not responding to modern medication it was found that Ayurvedic treatment could offer significant relief as well as improvement in laboratory parameters.
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OA03.17. Pilot retrospective observational study to evaluate efficacy of customized ayurvedic therapy on Type 2 diabetes exhibiting secondary failure of oral hypoglycemic drugs
Somit Kumar
January 2013, 32(6):40-40
Purpose: The data was retrospectively collected through third part unbiased documentation conducted under RUDRA program at The Arya Vaidhya Chikitsalayam and Research Institute. Obtained data was evaluated to study the efficacy of customized ayurvedic therapy in on Type 2 diabetes exhibiting secondary failure of oral hypoglycemic drugs. Method: Participants were retrospectively selected between Jan. to Dec. 2011 diagnosed with Type 2 Diabetes mellitus as primary or secondary morbidity during documentation. Out of 194 patients who visited our OPD with primary aim as management of their type 2 diabetes 27 cases found to have adequate baseline and endpoint data and satisfying the inclusion criterion were delineated, exhibiting secondary failure to oral hypoglycemic drug . At least 1 prescription claim for a sulfonylurea or a thiazolidinedione during study period along with metformin use include in the study. Secondary failure was measured for patients who initially achieved a Fasting and Post prandial blood glucose 126 mg/dl and 200 mg/dl but in due course of chronicity again rose above the said level, exhibiting secondary failure of oral hypoglycemic drugs Result: Participants (mean age, 50.034 (S.D. μ13.64) years; 55.6% female and 44.4 % males) who were known diabetic since 5.9185 (S.D. μ6.6) underwent a customized Ayurveda treatment with Allopathic oral hypoglycemic drugs as concomitant medication for average of 16.2 weeks. The mean baseline Fasting and Post prandial blood glucose was 163.26 (S.D. μ50.57) and 230.23 (S.D.μ 90.24244) and which was higher for the patients receiving a combination of metformin and sulfonylurea or thiazolidinedione. The mean Fasting blood glucose decreased to 131.49, and Post prandial 174.5 of patients as compared to baseline. This reduction in the Gycemic index was found to be statistically significant after administration of unpaired students 't' test at significance level of <0.05. Conclusion: Customized Ayurveda treatment was able to ameliorate the Fasting and Post prandial blood sugar levels in patients with secondary failure to oral hypoglycemic drugs with type 2 diabetes.
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OA03.18. "A comparative study of kati basti with sahacharadi taila and maha narayana taila in the management of gridhrasi (Sciatica)"
Gopesh Mangal, Gunjan Garg, S Radhey Shyam
January 2013, 32(6):41-41
Purpose: The symptoms seen in Gridhrasi can be well correlated with "Sciatica" in modern terminology. Moreover, the modern treatment of sciatica is not very satisfactory and includes use of analgesics and few surgical procedures which is often associated with many adverse effects Among the Panchakarma therapy; Kati Basti is reliable to control the disease. Hence an attempt is made to compare the effect of Kati Basti with Sahacharadi Taila and Maha Narayana Taila in the management of Gridhrasi Method: It was an open clinical study with a pre and post design, for the duration of 14days for both Kati Basti groups 90 patients, fulfilling the inclusion and diagnostic criteria, were selected and randomly divided into 2 groups with 45 patients in each group. In Group A, Kati Basti with Sahacharadi Taila was administered daily during the trial period while In Group B, Kati Basti with Maha Narayana Taila was administered daily. Result:
  1. Kati basti with Maha Narayan Taila group and Kati basti with Sahacharadi Taila group showed almost same percentage relief in all assessment parameters. Both group showed higest percentage relief in the Functional ability while no relief in the Aruchi
  2. Kati basti with Sahacharadi Taila is more effective to control Kapha dominance symptoms like Stambha, Graha, Gaurava and Tandra and also on walking distance and magnitude of Pain
  3. Kati basti with Maha Narayan Taila group is more effective to control vata dominance symptoms like Ruk, Toda, Numbness, Burning Sensation and Muhuspandana and also on the Functional ability , Sakthikshepanigraha and the functional disability.
Conclusion: Kati basti with Sahacharadi Taila and with Maha Narayan Taila is almost equally effective in the management of Gridhrasi but Kati basti with Sahacharadi Taila is more effective to control Kapha dominance symptoms while Kati basti with Maha Narayan Taila group is more effective to control vata dominance symptoms.
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OA03.12. Herbal socks an effective medication against plantar hyperkeratosis.
C Geethadevi, R Rajendran, R Radhai
January 2013, 32(6):35-35
Purpose: Plantar hyperkeratosis commonly called cracked heel is a common condition among adults. Causes for plantar hyperkeratosis are many and include genetic defects reflected in skin structure, allergic dermatoses, and paraneoplastic syndromes seen with particular forms of internal malignancy. Treatment for this condition could be possibly done using traditional herbs. The current study throws light on the cure of plantar hyperkeratosis using socks worn daily. Method: Solanum xanthocarpum powder and Aleo vera were subjected to different solvent extracts and its antimicrobial activity against isolated organism was studied. The solvent extract showing highest zone of inhibition was chosen and nanoparticle was synthesized by ionic gelification method and characterized physically and chemically. Synthesized nanoparticles were coated onto the socks using pad dry cure method. The antibacterial activity of the socks was then studied using AATCC 100 and 147. The nanoparticle treated socks was chemically characterized using FTIR analysis. The socks were then analyzed in vivo. Result: The synthesized nanoparticles were characterized using HRTEM analysis and it was spherical. The nanoparticles coated socks showed a better activity against the organisms isolated from patients having plantar hyperkeratosis. The activity of the socks was tested in vivo among 20 patients and this proved to be promising cure. The wash durability of the socks was effective until 20 washes. Conclusion: The results showed that the formulated socks were effective against treatment of cracked heel and it also proves to be antimicrobial in nature. The effective durability of the socks was due the control and sustained release of herbal extracts from nanoparticle. Plantar hyperkeratosis could burden immune compromised patients such as diabetes, these kinds of herbal socks would be a better option for this treatment than the conventionally used time consuming treatments.
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OA03.13. Clinical evaluation of Amrutadhya Guggulu & Lekhana Basti in Medodushti with special reference to Dyslipidaemia
F Ashwini Vinayak, I Nilesh Manohar
January 2013, 32(6):36-36
Purpose: Cardiovascular diseases (CVD) are the major cause of morbidity and mortality in our society with Dyslipidaemia contributing significantly to atherosclerosis. All components of Dyslipidaemia get the most attention because of the link between plasma lipids & CVD, as it is major risk factor for fatal diseases such as Coronary Artery Disease (CAD). As described in Ayurveda, Medodushtijanya Sign & Symptoms shows strikingly resemblance with Dyslipidaemia explained in modern text. Thus while treating the Medodushti, selection of Dravya should have criteria that help to Lekhana of excessive MedaKapha without Vayuprakopa & normalising the Agni both at the level of Jatharagni & Dhatwagni. Thus to assess the efficacy of Lekhana Basti & Amrutadhya Guggulu, present study was planned . Method: 30 clinically diagnosed & investigated individuals of Dyslipidaemia. Patients were selected from OPD & IPD of Arogyashala, NIA, Jaipur. Patients were administered Amrutadhya Guggulu in dose of 3g/day in three divided doses with 15 Lekhana Basti. Result: The results were highly significant in both Subjective as well as Objective parameters. Conclusion: Dyslipidaemia is very prevalent in today's society & the risk factor for cardiovascular disorders mostly seen associated with diabetes mellitus & Hypertension.Thus, it can be concluded that from the present clinical trial both the Amrutadhya Guggulu & Lekhana Basti are highly effective in management of the Dyslipidaemia. This study gave very effective, safe, & easily manageable management of Dyslipidaemia in cheaper rate.
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OA03.14. A clinical study on the effect of vamanakarma with navakashyaguggulu in kitibha kustha
Srinivasulu Mantha
January 2013, 32(6):37-37
Purpose: In present era due to drastic advancement in science and technology the present population are prone to more of intellectual work than compared to physical work leading to increased levels of psychological stress added to that involving in irregular dietary habits, taking oily and spicy food etc resulting in increased incidence of psychosomatic disorders. One such disease is Psoriasis in ayurveda that can be correlated with Kitibha kustha it is mainly due to vitiation of vata and kapha doshas. Acharya chakradatta described a pancha kashaya kwatha vamana in 50/3 and Nava kashaya guggulu in 53/20 chapter, which is used to evaluate the effect in kitibha kustha. Method: Patients diagnosed as kitibha kustha according to classical signs and symptoms were selected from o.p. and i.p. department of panchakarma, Dr.B.R.K.R.Govt.Ayurvedic college,Hyderabad. They were underwent a vamanakarma with panchakashaya kwath followed by shamana chikitsa with Nava kashaya guggulu for oral administration for 45days. Result: The assessment of treatment procedure was based on change in classical signs and symptoms of kitibha kustha. The results were found encouraging as there is significant reduction in syava (redness), ugrakandu (itching), parusha of twak (roughness of skin). Conclusion: Kitibha kustha is kapha predominant disease with vatanubanda. For kapha predominant dosha vamanakarma is best shodhana treatment and hence vamana is adopted alongwith kusthahara property of Nava kashaya guggulu.
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OA03.15. A clinical study on the effect of ksheera vaitharana vasti in the management of gridrasi w.s.r. to sciatica
N Krishnakumar
January 2013, 32(6):38-38
Purpose: Human beings are almost unique in standing upright posture balanced on two limbs. even though they are getting advantage of this posture,it also leads to considerable stress on the spine. the life style of a person has changed a lot in accordance with the time. As advancement of busy, professional and social life, improper sitting posture, jerking movements etc. all these causes undue pressure on the spine,as a result most common disorder of the spine low back ache occurs. Out of which 40% persons comes under sciatica. Gridhrasi is a soola pradhana vyadhi affecting the lower limbs with impairment of lifting of thigh. It can be compared with sciatica. In present study vaitharna vasthi mentioned in vangasena samhita in which goksheera as main ingredient is used to evaluate the effect in gridrasi. Method: Patients diagnosed as gridrasi according to classical signs and symptoms and positive SLR test were selected from O.P & I.P department of Dr.BRKR Govt. Ayurvedic Hospital.They were administered two cycles of vaitharana vasti in the form of yogavasti with gap of one week in between two cycles. Murchita tilataila is used for anuvasana. Saindava, guda, tilataila, amlika & goksheera are mixed in this order as vasthi vidhi. Result: The assessment of overall effect of therapy was based on both subjective and objective parameters. Subjective parameters include clinical features of gridrasi as per texts. Objective parameters include SLR test, numerical pain rating scale, oswestri disability index, X-ray of LS spine and MRI of LS spine. The results were found encouraging as there is significant reduction in pain & stiffness with improvement in straight leg raising. Conclusion: Vasthi is considered as the most powerful sodhana procedure and it is said to be ardha chikitsa. It is the most effective treatment for diseases which arising from vitiated vata. Since goksheera is the main in gradient, it is very effective in degenerative bony disorder or asthi dhatukshayajanya vikaras which is one of the main cause of sciatica.
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OA01.05. Effectiveness of simple and logical treatment in complete disc prolapse
R Parthasarathy
January 2013, 32(6):5-5
Purpose: To explain the effectiveness of 21 days inpatient treatment on a 46 year old male patient with complete disc proplapse who was suggested an emergency discectomy in a leading hospital. Method: To explain the case history with complete details of medicines used and treatments given with the responses observed before, during & after treatment with substantiating 3 MRI digital films & reports that were taken before, immediately after treatment and 3 months later.Also to have a small video of the patient sharing his experience.Treatments given were Abyangam, Elakkizhi, Navarakizhi, Matravasthi, Vaitarana vasthi, Madhu thailika vasthi & Pichu with 8 internal medications during the treatment course. Result: The patient who was unable to stand, sit & walk properly with the threat to lose his bladder & bowel control without discectomy had a dramatic recovery during discharge and 100 percent recovery in 3 months with ayurveda treatments alone, with out any supportive allopathic care. Conclusion: Though it is a well known fact that Ayuvreda work wonders with such conditions, this is an attempt to explain that these are not only because of specialized & sophisticated treatments but a simple and logical treatment can also be miraculous and also to emphasize that documentations like MRI reports before and after treatments helps is proper evaluation of the treatment results in addition to patients feedback.
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OA01.01. A case report on psoriasis
R Supraja
January 2013, 32(6):1-1
Purpose: To report a case of female aged 29 yrs presenting with complaints of itching all over the body and patches of 2 cms length covered by scaly lesions which are white in colour and on scrubbing powder like substances falls down and bleeding in drops. The case was diagnosed as Psoriasis by an allopathic doctor by 2010 and according to my view it was a twak rogam of pitta kapha dominance with slight vitiation of vata also.She was under medication from June 2012 to August 2012. To discuss the effects of 1. Guggulu tiktaka kashayam,madhusnuhi choornam,rajanyadhi choornam and durvadi tailam which are popularly in usage for skin diseases 2. To give a long term cure for psoriasis Method: The method is by treating the patient in out patient level by oral administration of medicine and external application of oil. 1. Gugulu tikthakam kasaya choornam 10gm was taken and 100 ml of water added to it and boiled till it reduction to 50ml and taken in empty stomach morning and evening 2. Madhusnuhi choornam 5gm and rajanyadhi choornam 5gm taken and mixed with hot water and taken after meals twice daily 3. Durvadi tailam is used for external application Result:
  1. The use of above mentioned drug in 15 days showed 70% reduction of itching all over the body. Continuation of the medicines for 1 month results in the disappearance of patches. After 1&1/2 months the scaly patches and wound disappeared & after 2 months the skin got its normal appearance 2. After the disappearance of the symptom also the patient is advised to continue medicines for 1 month and their is no reoccurrence till date. It is a result of single case study that has given results with these medicines. Further evaluation of cases will be needed to give extensive results.
Conclusion: The above mentioned medicines have given an effective cure to psoriasis .
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OA02.04. Wound healing property of Kanchanara [Bauhinia variegata Linn] - An experimental study.
Shilpa Hiremath, Pradeep
January 2013, 32(6):10-10
Purpose: Wound a clinical entity, is commonly seen as a result of various etiological factors like trauma etc. Kanchanara a plant origin drug. Many of the Nighantu's have mentioned vrana shodhana and vrana ropana properties of Kanchanara. Hence present study of evaluating wound healing property of Kanchanara bark in the form of churna and ointment [sikta taila base] preparations has been taken up. Method: Albino rats were the experimental model. 36 albino rats were selected and divided into 6 groups of 6 rats each. 3 groups were used for excision wound model and remaining 3 groups were used for incision wound model, one group being served as the control and remaining two group for the trial drug. Churna and ointment were used for both excision and incision groups. Albino rats were wounded under aseptic conditions using wound techniques suggested by Marton and Malone [1972] and also by hunts model[1969]. In case of excision wound area of wound was measured once in 4 days by using graph sheet. In case of incision wound tensile strength was found out by using tensinometer on 10th post wounding day. Result: The statistical values of both groups were compared with control group and it showed that: 1. Kanchanara ointment promoted epithelization, wound contraction and period of epithelization was reduced in case of excision wound. 2. In incision wound also Kanchanara ointment helps in increasing collagenation and tensile strength. Both ointment and churna group are highly significant when compared with control group. On comparison of ointment group with churna group it statistically showed insignificance. No untoward side effects were noticed during the trial and the wound, healed with minimal scar. Conclusion: Kanchanara ointment and its churna is an effective, safe and well tolerated therapy in the treatment of both excision and incision wound.
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OA02.05. Antimicrobial activity of Rasamanikya against different pathogenic microbes w.s.r. to skin disease
Poonam Kumari, RS Hiramath
January 2013, 32(6):11-11
Purpose: To evaluate antimicrobial activity of Rasamanikya; against 11 pathogenic microbes bacteria and fungi. Ayurvedic Rasaushadhi also possesses antimicrobial property. Rasamanikya is widely used in skin disease mainly so it may considered as it posses antimicrobial activity against skin disease causing organism. Method: Above mentioned Rasamanikya Rasaushadhi was tested for antimicrobial activity against common pathogenic microbes including skin disease causing microbes by culture and sensitivity method. Result: Rasamanikya exhibits good antimicrobial activity against many microbes. Conclusion: The present study of antimicrobial activity of Rasamanikya reveals that the drug have got good antimicrobial property against selected microbes. This study supports the therapeutic potential of the drug as it has inhibited the growth of microorganisms responsible for different diseases. However, proper understanding of Ayurveda and further developing the appropriate models and parameters for study of pharmacological activities of the Ayurvedic drugs is necessary.
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OA02.06. Importance of drug authentication and standardization as per API with the example of Alpinia species
KG Nini, Deepthi Mohan, TS Jyothi, D Induchoodan
January 2013, 32(6):12-12
Purpose: Ayurvedic system of medicine has become significantly more popular all over the globe because of its time tested safety and efficacy. Unprecedented demand for herbal drugs and ignorance of herbal drug collectors-which are mostly collected from wild sources-, has lead to adulteration of genuine drugs which affects the quality of final products. Method: In the present era, authentication and standardization in accordance with Ayurvedic Pharmacopoeia of India (API) is the strategy to ensure the genuineness of medicinal plants used in Ayurveda. Result: Different standard operating procedures are adopted to ensure genuineness, identity and quality of herbal medicines. It is also essential to establish internationally recognized guidelines for ensuring the raw material quality along with Ayurvedic parameters. Conclusion: Based on methods like comparative phytochemical analysis, organoleptic identification, macroscopy, microscopy and TLC of Alpinia species, this paper attempts to illustrate the importance of authentication and standardization of raw materials.
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OA02.07. Experimental evaluation of "yakritashula vinashini vatika" w.s.r. to hepatoprotective potential in albino rats.
Anita Mali, Sanjay Kumar
January 2013, 32(6):13-13
Purpose: According to the latest W.H.O. data published in April, 2011 death due to liver disease in India has reached 2.3% of total deaths. This stands 27th in the world. Till date, there is no effective medicine for treating hepatic disorders in modern medicine, so efforts have been made to search for effective Hepatoprotective drug. The purpose of the present study was to evaluate the Hepatoprotective activity of Yakritashula Vinashini Vatika (YSV) against Carbon tetrachloride induced Hepatotoxicity in rats. Method: The toxicant CCl4 was used to induce Hepatotoxicity at a dose of (1 ml/kg b. w.) as 1:1 mixture with olive oil. YSV was administered in the dose of (200 and 400 mg/kg .b .w. /day) orally for 28 days. And the results were compared with known standard drug Silymarin (100mg/kg b. w.). The Hepatoprotective effect of YSV was evaluated by the assessment of biochemical parameters such as SGOT, SGPT ALP, Total Billirubin, Serum Protein, Lipid profile. Result: The toxic effect of CCl4 was controlled in the animals treated with the YSV by way of restoration of level of liver function biochemistry similar to that of the standard drug Silymarin. Among the YSV treated groups significant Hepatoprotective activity was observed. In the histopathological studies, the liver sections of rats treated with YSV 200 & 400 mg/kg respectively, a normal hepatic architecture was seen with only moderate accumulation of fatty lobules and mild degree of cell necrosis, clearly indicating the protection offered by drug. Conclusion: From the results it can be concluded that YSV possesses Hepatoprotective effect against CCl4 induced liver damage in rats.
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OA02.08. Chick embryo model an experimental model for drug discovery in ayurveda.
Ekta Tomar, Nilesh Suryawanshi
January 2013, 32(6):14-14
Purpose: There has been a continuous and increasing demand for newer experimental models in various studies like Teratogenicity, Pathogenicity, carcinogenicity, mutagenicity, stem cell research, viral studies, in preclinical studies to generate a database for ayurvedic drugs. To serve this purpose Chick Embryo as an experimental model is proposed because of its rapidity, validity Easy handling and availability throughout the year. And as it is an exvivo model, the ethical problems can be lessened. Method: The fertilized eggs are cleaned by 70% ethanol and kept in a 370 C humidified incubator. These eggs can now be taken from 0 embryonic development day (EDD) till hatching, depending upon the type of study. To observe the changes after inducing the drug the model can be visually assessed and are photographed for further analysis. The tissues can be excised and taken for histological studies and also the various dyes can be injected to visualize the dynamic changes in the growth patterns. With the aid of sophisticated technique the chick embryo can be taken for shell less studies. Result: Hence, it can be concluded that the Chick Embryo model may be one of the best model in recent trends for drug discovery and it can be also used to establish the preclinical parameters for the preexisting Ayurvedic formulations. This is an easy model to validate and generate a data base for ayurvedic drugs. Conclusion: Hence, it is proved in a larger extant that chick embryo may be an ideal and It can also be one of the widely preferred model for drug discovery in Ayurvedic research. There is a need of present era to have an scientific data, this model can help our to do so.
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OA02.09. Evaluation of varatika bhasma for its ulcer protective effect on albino rats.
Paritosh Bhatt
January 2013, 32(6):15-15
Purpose: Gastritis leadind to G.I.ulcers is a very prevalent metabolic and life style disorder. Many a times it is condition which arise due to various medications like NSAID's. Drugs effective in Ulcer protection is the need of the hour. Medications such as sucralfate in conventional system do work but in higher dose and with limitations. Thus, present study has been carried out, to evaluate efficacy of Varatika bhasma in ulcer protective activity with standard control as Sucralfate in aspirin induced ulcer. Method: Varatika bhasma was prepared by shodhana with kanji, bhaavana with kumari swarasa and subjecting to gajaputa. Further it was analyzed and used for experimental study. Winstar strain albino rats of either sex was taken in 3 groups with 6 rats in each group. Control group with food and water, standard with sucralfate and test with varatika bhasma was given for 6 days. on 7th day ulcer was induced with aspirin. later rats were sacrificed to cut open the stomach and to study the ulcer index and histopathology. Result: When compared to Sucralfate for ulcer protective effect, Varatika Bhasma shows significant result in lower doses. (Sucralfate 1 gm 6 hourly and Varatika Bhasma 250 mg twice daily). In ulcer index and histopathology studies, there were less / no ulcers found in the group treated with Varatika Bhasma in comparison with Sucralfate and Control group. Conclusion: For the ulcer protection, Varatika Bhasma provides better and promising result when compared to Sucralfate. This also cuts the cost of medication and time constrain for the administration of the medicine.
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OA02.10. Influence of kalyani raga on fetus and pregnant women
Deepthi Krishna
January 2013, 32(6):16-16
Purpose: Pregnant women are more alert to their environment which greatly influences them. Prenatal stimulation through music allows expectant mothers to connect with their unborn baby. This helps to lower the mother's anxiety level and neonatal stress too. Auditory system is the only one that establishes a connection between the foetus and the outer world . So this we can stimulate the most. The intension of the study is to see the efficiency of music on foetus as well as pregnant women .So it can be effectively used as a part of Garbhini paricharya. Method: Each pregnant lady will be explained about the influence of music especially the Kalyani raga and later they will be given a CD of Karnatic Music of Kalyani raga and is instructed to hear it for 20 minutes daily for a period of 20 days . Result: The study shows very good influence in both fetus and pregnant women. Conclusion: On the basis of pancha panchaka siddantha shabda is the attribute of akasha mahabhoota which is used in the form of music given through srothraindriya interacts with manas and giving message to the atma. By this perception the pregnant lady gets the prassannata of atma indriya and manas and this influence the fetus which is in her womb and even we can cultivate a srasta samskara.
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OA02.11. Alpha‑amylase inhibitory property and antioxidant potential of Saraca indica and Polyalthia longifolia bark extracts
P Gayathri, GP Jeyanthi
January 2013, 32(6):17-17
Purpose: The present study was designed to study the alphaamylase inhibitory property and antioxidant potential of the various solvent extracts of the bark of two medicinal plants Saraca indica and Polyalthia longifolia. Method: The yield percentage of aqueous, ethanol, ethyl acetate, hexane and chloroform extracts of Saraca indica and Polyalthia longifolia bark were assessed by extracting 5 g of the dried plant material in 25 ml of the respective solvent in a shaker at 40 degree celsius for 48 hours. Filtered and evaporated the solvents at room temperature. Aqueous extract was subjected to lyophilization. The residues were weighed to calculate the yield. Total antioxidant potential of the extracts were assessed by FRAP assay and compared with standard ascorbic acid. Inhibition of in vitro lipid peroxidation of the potent extract was studied using linolenic acid micelles as model system. Alphaamylase inhibitory property of the extracts was studied by the method given by Bernfield (1995) and compared with that of the standard inhibitor acarbose. Also the type of inhibition of the potent extracts was studied by Dixon plot. Result: The results revealed that the yield percentage was highest for ethanolic extracts of Saraca indica and Polyalthia longifolia bark. Among all the tested extracts the ethanolic extract of both the barks found to possess highest antioxidant potential and alpha amylase inhibitory activity followed by the aqueous and ethylacetate extracts. Hexane and chloroform extracts possessed lowest antioxidant and amylase inhibition potential. The ethanolic extracts presented good inhibition of in vitro lipid peroxidation. The type of inhibition of amylase showed by the ethanolic extracts was found to be competitive. Conclusion: To conclude, the ethanolic extracts of Saraca indica and Polyalthia longifolia bark were found to possess good antioxidant potential and also showed efficient inhibition of the enzyme alphaamylase.
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OA02.12. Poly herbal ayurvedic formulation for the development of anti‑miliaria cotton fabrics
V Rajalakshmi, R Rajendran, R Radhai
January 2013, 32(6):18-18
Purpose: Miliaria is also known as Sweat rash or Prickly heat, common aliment of the eccrine sweat glands that often occurs in conditions of increased heat and humidity. It is especially prevalent in babies and infants. Miliaria crystalline is the one which cause multiple tiny blisters resulting in rapidly evolving noninflammatory vesicles. The present study was mainly carried out to explore the use of herbal plants primarily Neem (Azadirachta indica) and Mint (Mentha arvensis) leaves for the development of AntiMiliaria cotton fabrics using AATCC methods. Method: Methanolic extracts of the poly herb were prepared. Microorganisms were isolated, microbiologic and histological features of the samples were evaluated. The preliminary antimicrobial activity of different extracts was performed by agar well diffusion method. The phytochemical analysis of the extracts was evaluated using standard procedures. After evaluation, the crude poly herbal extracts were coated on to the cotton fabrics using pad dry cure method. The antimicrobial assessment of poly herb treated cotton fabrics assessed using AATCC standard methods. Result: The organisms isolated from the Miliaria samples are Staphylococcus epidermis. The preliminary results showed that Neem (Azadirachta indica) and mint (Mentha arvensis) leaves having better antimicrobial activity against Staphylococcus epidermis. The Poly herbal treated fabrics were further characterized chemically. The Antimicrobial assessment of poly herb treated cotton fabrics showed increased antimicrobial activity than control fabric. It showed 100% bacterial reduction in poly herb treated fabrics until 10 washes. Conclusion: The use of medicinal plants is a worldwide phenomenon. Every part of the world prefers medicinal herbs to treat disease than commercially available antibiotics. Further in vivo studies will help to understand the mechanism of action of antimicrobial fabrics on the Miliaria infection.
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OA02.13. Effects of drakshavaleha in developing mice embryo
Sunil Kumar
January 2013, 32(6):19-19
Purpose: Due to antianemic properties and nutritional values, Drakshavaleha has been used as a Naimittika Rasayana (promoter of specific vitality in specific disease) to a woman during her pregnancy expecting a good health of both mother and her offspring. The objective of the study was to investigate a protective effect of Drakshavaleha against Cyclophosphamide (CP) induced growth retardation in mice pups in the terms of body weight and CRL (crownrump length). Method: Group I (Control): Pregnant mice (n=10) received 0.2 ml of distilled water intraperitoneal on day 11 of pregnancy as vehicle. Group II (Drakshavaleha): Pregnant mice (n=10) received Drakshavaleha (16g/kg) orally from day '0' to day '18' of pregnancy. Group III (CP): Pregnant mice (n=10) received CP (10mg/kg) intraperitoneal on day 11 of pregnancy. Group IV (CP + Drakshavaleha): Pregnant mice (n=10) received CP (10mg/kg) intraperitoneal on day 11 under cover of Drakshavaleha (16 g/kg) orally from day '0 to day 18' of pregnancy. Result: In Group III, growth retardation and decreased fetal weight were seen when CP was injected on 11th day of gestation. Amongst litters whose mothers received the drug (CP) on same day in same dose under Drakshavaleha cover the pups were seen with significant weight gain which however was lower as compared to the pups born to mothers with administration of Drakshavaleha alone (Group II). CR length was also of same conclusion in group II and group I respectively. Conclusion: The above observations suggest that Drakshavaleha increases the size and weight of pups when it given to the mother mice during their gestation period.
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OA01.02. Management of infertility subsequent to endometriosis -A study
A Sindhu
January 2013, 32(6):2-2
Purpose: To explore the efficacy of Ayurvedic intervention in infertility subsequent to endometriosis by retrospective analysis of clinical encounters. Method: A female aged 26 years who underwent two laparoscopic aspirations of the chocolate cysts, adhesion detachment for body of uterus and ovaries with kinked tubes was managed with Ayurvedic medicines on an OPD level. Result: Within three months, the menstrual cycles became normal and painless. The USG after course of treatment showed no cysts and the adhesions were also not indicated. The same month the patient responded positive to pregnancy test. A full term normal healthy baby girl was delivered after 8 months. Conclusion: The management of endometriosis, which is vatiki yoni roga, based on the manifestations in the patient, was given vata pitta hara treatments, the kalayanakagritham in the medication reduced the stress level and the punarnavadi kwatha with chandraprabha vatika and menocalm reduced the inflammatory conditions and reduced pain. Varanadi kwatha was included along the medication to do the kaphamedohara function and this combination worked on the cysts and the patient felt ovulatory cramps. With the vanishing of the cysts sukumaram kwatha and kalyanaka kwathas were added in the medication along with phalsarpis.
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OA02.14. Krimigna action of vidanga against clinical isolates of multidrug resistant bacteria, importance of correct identification.
Usha Patil
January 2013, 32(6):20-20
Purpose: Vidanga (Embelia ribes) has been described as one of the most potent krimighna dravyas in ayurvedic literatures. However, clinical studies have not unequivocally demonstrated the antibacterial activity of the drug when used against the bacterial pathogens of clinical importance. Recently, information is emerging regarding the confusion in the scientific community regarding the identification of authentic drug vidanga against Embelia robusta. Hence, the present work was designed to evaluate the antibacterial activity of different extracts of vidanga against clinical isolates of multidrug resistant bacteria. Method: The raw drug of Vidanga was collected from Ludhiana market and powdered using standard method. The crude drug was subjected to preliminary phytochemical analysis and the drug was extracted in aqueous, ethanol, methanol and chloroform solvents. Antibacterial activity of each extract was evaluated against the multidrug resistant clinical isolates of Klebsiella spp. Proteus spp. Salmonella spp. Citrobacter spp. E.coli, Bacillus spp. Result: Various extracts of the crude drug vidanga showed moderate to nill activity against most the clinically isolated bacterial agents. Conclusion: Observed degree of antibacterial activity directly reflects the characteristics of the constituent chemicals. The chemicals present in the drug may not be having soaring antibacterial effect. These observations might be attributed to the wrong identification of E.robusta to E. ribes.
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OA02.15. Anti-inflammatory and anti-proliferative activity of terpenoid fraction isolated from plectranthus hadiensis.
Darsan Menon, Jagathala Sasikumar
January 2013, 32(6):21-21
Purpose: To evaluate the use of this plant in Ayurvedic formulation for treating various inflammation related ailments. Method: TLC, HPTLC and GCMS studies of the fraction confirmed the presence of terpenes. BSA denaturation inhibition, HRBC membrane stabilization and Platelet aggregation inhibition studies showed the antiinflammatory activity of the terpene fraction. MTT assay (on HCT15) and DNA fragmentation assay and Acridine orange Ethidium bromide staining was used for checking anti proliferative activity and apoptosis inducing capacity of the fraction. Result: The phytochemical studies proved the presence of terpenes. The anti inflammatory assays showed the positive effect of the fraction on inflammatory conditions and proliferative studies showed the apoptosis inducing capacity of the fraction. Conclusion: Our studies thus corroborated the use of this plant in various formulations used in Ayurveda. And further studies are being performed to elucidate the molecular mechanism of action of the terpenoid fraction on the cancer cells.
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OA02.16. Ayurvedic nanomaterials: Preparation and characterization of ginger loaded polymeric nanofibers for drug delivery applications
D Ravi Shankaran, M Roshan Jesus, R Sarika
January 2013, 32(6):22-22
Purpose: The purpose of this study is to combine nanotechnology and ayurveda to develop novel ayurvedic nano materials with enhanced functionalities towards betterment of the clinical practices. In this context, we have fabricated ginger loaded polymeric nano fibers. Ginger is an important ayurvedic material because it exhibits a wide range of biological and pharmacological activities including antioxidant, antiinflammatory, antibacterial, antifungal, antiparasitic, anticancer and detoxifying properties. Incorporation of ginger with polymeric materials enables high-performance drug delivery systems. Method: Nano fibers are produced by electro spinning method using poly(methyl methacrylate) (PMMA) and gelatin polymers. Electro spinning is a simple and versatile method for fabrication of nano fibers with high surface to volume ratio. The electro spinning parameters are optimized with respect to flow rate, voltage between the two electrodes, tip collector distance to obtain fine nano fibers without beads. After optimization, ginger loaded nano fibers are fabricated by mixing ginger with polymer before electro spinning. Result: The fibers were characterized by various techniques such as optical microscope, Fourier transform infrared spectroscope (FTIR), UVVis spectroscope, atomic force microscope (AFM) and high resolution transmission electron microscope (HRTEM). The studies showed uniform and smooth fibers (hollow fibers) loaded with ginger. The average diameter of the nano fibers is in the range of 100 to 600 nm. The UVVis studies showed the release of the drugs with respect to time depending on the morphology of the fiber and medium. Conclusion: Ginger loaded nano fibers are successfully fabricated with smooth surface without beads. The ginger release studies demonstrated a slow release of ginger from the nano fibers. The results demonstrate that the ginger loaded nano fiber could be a good candidate to manage various diseases, specifically, rheumatic diseases, joint pains and migraine. This work provides an opportunity to expand the medical benefits of combined nanotechnology and ayurveda.
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OA02.17. Medicinal plant tissue culture and its ayurvedic perspective.
Ashakiran Kilankaje
January 2013, 32(6):23-23
Purpose: Introduction of Plant tissue culture (PTC) concept to the Ayurveda realm. Method: 1. Analysis of principles the plant tissue culture based on the literature review and real wet lab images of tissue culture 2. Analysis of ayurvedic principles which are relevant in the context 3. Logical concept development. Result: Plant tissue culture is based on the natural ability of plant cells to grow in to fullfledged organism, called as totipotency. Plant cell can exhibit totipotency only when it is placed in a suitable micro condition where it is supplied with all essential nutrients such as minerals, water, light source, carbon source and air. Two branches of tissue culture a. micropropagation b. in vitro adventitious root development (Sivakumar 2006), are relevant for ayurvedic industry in purview of increasing demand for good quality raw materials and decreasing wild sources of medicinal plants. Ayurvedic concept of Anukta dravya grahana (Reddy 2008; Kusuma and Joshi 2010) describes the need for understanding the properties of an undocumented drug or medicinal plant experimentally before considering it as an ayurvedic drug. Ayurvedic system dravya guna vijnana is for understanding and classification of medicinal plants based on their seven fold properties (Valiathan 2003). The concept of 'Abhava prathinidhi dravya' (Padma et al. 2010) explains the situations where original drugs are substituted with substances of similar qualities, which were prescribed in case of several unavailable or rare drugs. The efficacy of medicinal plants or plant part produced through tissue culture has to be determined even though those are botanically and genetically the same. Rasanirdharana method (Dhyani 2008) can be combined efficiently with phytochemical screening for this purpose. Conclusion: Plant materials produced through PTC can be ideologically acceptable for ayurvedic industry when principles of plant tissue culture is analysed in detail in the light of certain ayurvedic principles.
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OA03.01. Biomedical studies on the classical ayurvedic treatment of rheumatoid arthritis in AVT, Coimbatore (19762011): After the biomedical auscultation, Ayurveda at a turning point?
Talpain Olivier
January 2013, 32(6):24-24
Purpose: In India today Ayurveda lacks recognition and is underused. Modern research seems to be a key in Ayurveda's recognition. But it did not show much result. Why is it so? The relation between Ayurveda and biomedicine might impact the results of the biomedical research on Ayurveda. How would it happen? Method: Through a casestudy: Two biomedical studies on the classical ayurvedic treatment of rheumatoid arthritis at the Ayurvedic Trust (AVT), Coimbatore : WHOICMR (1976-1984) and NIHNCCAM (2005-10) allow a comparative approach with an historical perspective. An ethnographic approach (interviews ; participative observation ; literary research) to describe actors' representations, capabilities, practices and relations within a specific context. With an anthropological approach (dependance), the two studies' examination as development projects through project analysis tools (objectives, functions, means, roles, achievements). A comparative examination through parameters assessed for each study: a) Objectives' achievement; b) Ayurveda's dependance on biomedicine according to the functions of the studies projects; and for each actor (Ayurveda vs biomedicine): c) Interest for the objectives; d) means and roles according to the functions. Result: A)Biomedical studies on Ayurveda do not aim at a better recognition of Ayurveda: our case study is an exception. B)Biomedical research on Ayurveda, its results and its impact are significantly dependent on biomedicine in its relation to Ayurveda. C)The historical perspective shows a development of Ayurveda's abilities in research: a) higher education of ayurvedic physicians and researchers; b) more experience of and expertise on research; c) better scientific communication tools and expertise. Conclusion: The historical perspective indicates a movement towards Ayurveda's emancipation of biomedicine regarding research and the reformulation of its own agenda. Further research might include issues like the role of research in the recognition of Ayurveda and the overall relation between Ayurveda and biomedicine, specifically regarding the integrative approach. Social sciences might help.
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OA03.02. The effect of kutaja pratisaraniya kshara in the management of ardra arshas.
Avnish Pathak, BN Yashawanth
January 2013, 32(6):25-25
Purpose: To evaluate the effect of Kutaja Pratisaraniya Kshara and Apamarga Pratisaraniya Kshara in the management of Ardra Arshas and to compare the effect of both the Groups. Method: Cases presenting with classical signs and symptoms of Ardra Arshas were selected and randomly allocated into two groups i.e. GroupA and GroupB .In GroupA Apamarga Pratisaraniya Kshara was applied and in GroupB Kutaja Pratisaraniya Kshara was applied. The signs and symptoms of Ardra Arshas i.e. bleeding per rectum, pain, defecation, tonicity of anal sphincter, sloughing of the pile mass and size of Arshas was assessed before and after the completion of treatment. Result: After the 30 days of treatment with Kutaja Pratisaraniya Kshara provided significant relief in pain by 100%, in bleeding by 97.61%, in defecation 100%, slough by 100%, in colour of pile mass by 98.33%. in tonicity of the anal canal by 95% and in size of pile mass by 98.33% ,and no recurrence noticed. After the 30 days treatment with Apamarga Pratisaraniya Kshara provided significant relief in pain by 100%, in bleeding by 97.7%, in defecation 95.5, in slough by 100%, in colour of pile mass by 98.1%. in tonicity of the anal canal by 95.2% and in size of pile mass by 96.6% and no recurrence noticed. On the basis of comparison of the effects as mentioned above it can be said that the application of Kutaja Kshara provided better relief in pain, defecation, slough and size of the pile mass of the patients in comparison to Apamarga Kshara. Conclusion: Group B cases showed better improvement when compared to Group A However all 20 cases of Group A and 20 cases of Group B showed good results.
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OA03.03. A clinical study on effect of yoni prakshalan with pancha valkal kwatha in the management of kaphaja yonivapada w.s.r. to candida albicans.
Prabhavati Bhattar
January 2013, 32(6):26-26
Purpose: Ayurved has elaborated Gynecological disorders under the entity of yoni vapadas.Kaphaj yoni vapat is one among the twenty yonivapadas, which shoes the symptoms of picchila yonisrava along with yoni kandu. All females of reproductive age group are prone for kaphaj yoni vapat at some time or other and is important Gynecological disorders now a days, in spite of several researches done and plenty of medicines in various forms being available now a days. Pancha valkal kawatha is used for stanika chikitsa(yoni prakshalan), these drug having the qualities of stambhana,kashay rasa, sotha hara and kapha shama beneficial for yonirogas. In this clinical study pancha valkal kwatha has shown significant improvement in white discharge, itching and backache. Method: Research conducted on 10 patients from IPD & OPD of Prasuti Tantra & Stree Roga of SDM College of Ayurveda, Hassan. The selection was done on the basis of chief complaints of Kaphaj yonivyapat such as vaginal discharge, itching associated with backache and presence of Candida albicans was proved by vaginal smear. Sthanik chikitsa with Panch valkal kwatha was given for duration of 7 days and patients were asked to maintain local hygiene. Follow up was for 1 week. Result: Out of 10 patients, 6 patients were totally cured from the symptoms and mild improvement was observed in the remaining 4 patients at the end of treatment. Conclusion: The drug Pancha valkal kawatha is kapha shamaka, stambhaka and having the properties like astringent, antiseptic (kashaya rasa) and wound healing (vrana ropana). Because of these properties it helps in increasing local cell immunity and prevent recurrence of symptoms in patients.
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OA03.04. To evaluate the effect of "Kadalikandadi kshara yoga" in the management of vataja ashmari"
B Sujata Waddar, Satish Annigeri, P Hemanthakumar
January 2013, 32(6):27-27
Purpose: In current surgical practice we are facing problems in treating Ashmari disease effectively even with all modernized facilities, and are insufficient to reduce the prevalence of Ashmari and health care cost. Method: 20 diagnosed cases of Vataja Ashmari were selected for study and recorded through proforma designed for single group of observational study.And To evaluate the effect of "Kadalikandadi kshara yoga" in the management of Vataja Ashmari"Drug has administered through orally with water. Result: In this series of 20 patients of Ashmari, 20% patients were cured i.e. their stone was removed. 30% patients were markedly improved i.e. either their only stone was removed or it was broken into pieces or they showed 100% relief in their symptoms. 25% patients either showed reduction in the size of the stone or marked relief in their sign and symptoms. Remaining 25% patients showed no reduction in the size of the stone. Conclusion: The stones, which are passed, are maximum from ureter. Which shows significant level expelling action of the trailed drug. From the study it can be concluded that the action of the drug is encouraging in subjective part rather than objective, however duration of the treatment should be considered.
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OA03.05. A clinical study on the effect of vamana in anartava wsr to secondary amenorrhoea
Monika Chauhan
January 2013, 32(6):28-28
Purpose: Anartava have been described by Sushruta and Vagbhata as non appearance of artava. The doshas obstruct the passage or orifices of channels carrying artava (artava vaha srotasa), thus artava is destroyed. Aggravated kapha and vata obstruct the passage of artava, thus menstrual blood is not discharged. So anartava is a Kaphaavrittvata predominant disease. Panchakarma is the most essential part of Ayurveda treatments. It is preventive, preservative, promotive, curative and rehabilitative therapy. Vamana karma has been considered as the best line of treatment for the kaphaja disorders Vamana is clearly indicated in presence of Kaphaavritta vata lakshanas i.e. Anartava and Artava kshaya in our classics. Method: Research was conducted on 4 patients from IPD & OPD of Prasuti Tantra & Stree Roga department of SDM College of Ayuveda, Hassan. The selection was done on the basis of chief complaints of anartava (secondary amennorhoea) irrespective of duration. In pathological point of view USG was carried out before starting the course of treatment. As purvakarma snehana and swedana was carried out according to deha bala and prakrati of patients. Vamana was given to patients as pradhana karma and followed by samsarjana karma. The follow up was one week. Result: After treatment,out of 4 patients, 3 patients got their mensus within time period of one week and one patient was remain unchanged. Conclusion: Vamana is one among the Shodhana procedures, through which Doshas are eliminated through Urdha Bhaga. It is a Doshapratyanika Cikitsa for Kapha Dosha because the main seat of Kapha is Uras/Amashaya & principle is to eliminate vitiated doshas from the nearest route. Just like the flower, fruits and branches which are destroyed at once as soon as the tree is rooted out, the diseases originated due to excessive Kapha are subdued after the elimination of Kapha through the process of Vamana.So, Vamana removes kapha (saumya) substances resulting into relative increase in agneya constituents of the body, consequently artava also increases.
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OA03.06. A clinical study to evaluate the efficacy of amritadya guggulu on elevated lipid profile.
U Ajay Bhat
January 2013, 32(6):29-29
Purpose: Hyperlipidaemia has gained world wide interest in its ability to participate in the pathology of atherosclerotic diseases like coronary heart disease (CHD) which dominates the scenario of diseases causing morbidity and mortality in the world. Hyperlipidaemia is a term used to denote raised serum levels of cholesterol or triglycerides or both. Raised cholesterol is estimated to cause 18% of the global cerebrovascular disease and 56% of global ischemic heart disease. Overall this amounts to about 4.4 million deaths (7.9% of total) annually. Raised total cholesterol is a major cause of disease burden in both the developed and developing world as a risk factor for ischemic heart disease and stroke. Every 1% decrease in cholesterol decreases CHD risk by 2.5%. Method: Randomized single group, single intervention observational study of sample size: 30. Assessment was done based on lipid profile values pre and post treatment. One tab "Amritadya Guggulu", 475mg TID with water, after food, for a period 30 days. Follow up was taken on 31st day. Result: After treatment S.Cholesterol showed an average of 21.96% decrease, On S.LDL at an average of 30.47% decrease, On S.VLDL average of 20.77% decrease, S. TRIGLYCERIDES average of 26.32% decrease at p<0.001 respectively. S.HDL showed an average of 1.40% increase at p>0.5. 60% of patients had an average increase in S.HDL by 9.27% and 28.30% decrease in other parameters, however 40% of patients had an average decrease of 8.62% and 23.01% decrease in other parameters in S.HDL. Conclusion: Amritadya guggulu has given significant result on elevated lipid profile, even though it has decreased S.HDL in minority patients, the change may be corrected, subject to lifestyle changes.
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OA01.03. Emergency management of pakshaghata - A case study
Prasan Shankar
January 2013, 32(6):3-3
Method: Pakshaghata, is a vatavyadhi. It can be correlated to the biomedical cerebrovascular condition called 'stroke'.The lakshanas include, ruja, vakstambha, etc. It's types are kaphanubandha and pittanubandha. Even though pakshaghata is a vata vyadhi, and mentioned in the nanatmaja vataja vikaras of charaka, it is not a shuddha vataja condition. There is samsarga of Pitta and kapha, clearly mentioned by Susrutha and Madhava nidana.In all the above explanations it is clear that raktadushti leading to vata prakopa is the underlying cause of the disease. The management of pakshaghata being reported in this paper is a case of ischemic stroke. Patient manifested with In the initial stage, treatment followed was teeksha nasya karma, which is akephepakavat chikitsa line of treatment as mentioned by Acharya Susrutha and Astanga sangraha for the purpose of reversing mada, murcha or sanyasa which is the pittaavrita vata stage of the disease. Once reversal of initial stage of pittavrita vata was accomplished, mridu virechana karma, svedana, abhyanga and basti were done for treating kaphaja and vataja stage of the disease and restore dosha balance. Nasya 8 drops in each nostril, Virechana Gandharva Hasta Eranda Taila 1030ml+30ml Dugdha, Agni alepa, Basti Anuvasana 80ml Brihat saindhava taila, Niruha 500ml mahamanjistadi kashaya. Result: After the course of treatment which lasted 15 days there was considerable reversal of symptoms. The recovery was promising and worth documenting.The results and discussion will be presented during the presentation. Conclusion: The above mentioned protocol to treat atyayika cases of pakshaghata is unique. The recovery was promising and worth documenting.
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OA03.07. "A comparative clinical study to evaluate the therapeutic effect of shivagutika in patients with H.I.V infection"
L Abhishek Anil, G Shrinivasa Acharya
January 2013, 32(6):30-30
Purpose: HIVAIDS is the most dreaded challenge that the today's medical world is facing! As patients do not have many options , they tend to look at ayurveda to help improve their condition clinical presentation of HIV is akin to the description of Rajayakshma characterized by involvement of multiple srotas and presenting with diarrhea, cough, fever and similar other symptoms . Shiva guttika is used here as a rasayana to improve the immunity. Method: A Single blind comparative clinical study with Pretest & Post test design. The patients were randomly categorized into two groups as shivagutika group and ART group consisting of 20 patients each Shivagutika group In this group the 20 patients were treated orally with shivagutika in a dose of 12 grams od, for 6 months ART group In this the patients were treated with ART for six months. Result: The criteria's selected for the evaluation like Cough, Dyspnoea, fever,body weight, HB%, ESR, CD4 count etc all were statistically analyzed. Following medication with shivagutika the value of cd4 count was 567 in comparison to initial value of 391. in the ART group the initial value of 417.6 increased to 447.6 following treatment. Conclusion: CD4 count affirms the therapeutic benefit of shivagutika in HIV infection /AIDS beyond doubt Various other vyadhi hara rasayanas can be used in the management of immuno compromised conditions and in reoccurant diseases.
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OA03.08. Clinical study of shaliparni ksheer paka in the management of hypertension
Preeti , Balakrishna Sevatkar
January 2013, 32(6):31-31
Purpose: Hypertension is reported as the third ranked factor for disability adjusted life years and is one of the primary risk factors for heart diseases and stroke, the leading cause of death worldwide. Overall, approximately 20% of world's adults are estimated to have hypertension. However, there is no definite term given in Ayurveda which clearly represents the disease but many scholars have tried to suggest some appropriate names to hypertension on the basis of their research and pathogenesis of the disease like Dhamani paripurnata, Uccharaktachapa, Siragata vata, Raktagata vata, Avritta vata roga, Rakta sampeedana etc. For its treatment, use of lifelong administration of antihypertensive drugs leads to many side effects. Hence, the present study has been under taken with the hope of searching out a better, safer, low economic remedy for the disease by evaluating the therapeutic effects of Shaliparni ksheer Paka and comparing it with the effects of allopathic drug Tab. 'Telmisartan' in the management of hypertension. Method: Clinical study was carried out on 60 patients of hypertension, selected randomly from OPD/IPD of Arogyashala, N.I.A., Jaipur which were categorized into two groups. 30 Patients of Group A were treated with control drug Telmisartan - 20mg or 40 mg, OD and 30 patients of Group B were treated with Trial drug Shaliparni Ksheer Paka, (Ch. Chi. 28/9), 150 ml, twice a day for 45 days. Results before treatment and after treatment was compared and analyzed statistically. Result: The study reveals that Patients in Group A showed more improvement in reducing the blood pressure whereas that of Group B showed more improvement on the symptoms produced in hypertension and the cholesterol level which was statistically significant. Conclusion: The drug Shaliparni Ksheer Paka can be used efficiently in the management of hypertension.
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OA03.09. Effect of local application of swetaaparajita moola & chitraka moola along with Ewe's milk on vitiligo (switra) in children
Sharvari Deshpande, U Shailaja Rao
January 2013, 32(6):32-32
Purpose: To find the efficacy of local application of Swetaaparajita moola & Chitraka moola along with Ewe's milk on vitiligo (switra) in children. Method: All the patients were given classical Virechana with 20 gm. Aragvadha phalamajja, after performing Pachana with Trikatu churna, internal Snehana with Moorchita goghruta, Abhyanga with Moorchita tilataila as per classical method. Then treated group patients were treated with local application of Swetaaparajita moola & Chitraka moola along with Ewe's milk, while placebo group patients were treated with arial roots of Vata (Neghrodha) on lesion once in morning & then exposed to sunlight for 15 min. for period of two months. All the patients in both groups were given khadiraodaka to drink. Result: The two months treatment statistically significantly increased the number of black spots in the lesion on an average by 31% and improved the colour of the patches towards the normal on an average by 38.33% while there was 19% reduction in size of the patches. Conclusion: The effect of the trial drug was seen significant in increasing the black spots and alteration in color, but reduction in size was comparatively less.
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OA03.10. Public health initiative on swarnamrita prashana: A multicentric trial
Arun Raj
January 2013, 32(6):33-33
Purpose: Ayurvedic preventive measure to increase immunity (Vyadhikshamatwa) among children of age group 016 years. Method: Swarnamrita Prashana (herbomineral formulation) a traditional recipe for child growth, memory enhancement and also to promote longevity and immunity were administered to children between 016 years once a month on Pushyanakshatra day. The study started on 29th May 2009 and still going on at 15 centers. Till date 51 cycles of Swarnamrita Prashana have been administered. Anthropometric measurements and complete medical and social history were recorded. Result: Overall 3,76,903 doses of Swarnamrita Prashana have been administered to children in this public health initiative. Public response was assessed through questionnaire after the completion of 21 (monthly) doses. Parents reported improvement of mental and physical health among 94.73% children, 56.14% children were free from recurrent respiratory tract infections in past 6 months, 79.82% improvement in gastro intestinal tract complaints with 92.10% parents volunteered to spread to their neighbours about Swarnamrita Prashana and its benefits. Conclusion: Comprehensive controlled clinical trials with immunological profile determination can only be opened for wide use in National Health Programme for the benefit of children suffering from immune deficiencies and malnutrition. Ultimately, Ayurveda could improve the quality of life through health promotional strategies by developing integrated and multi sectorial approach for population based prevention interventions.
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PA02.05. Pharmaceutical and analytical evaluation of Lasuna Kshirpaka w.s.r to charaka and sharangadhara methods.
Nilesh Suryawanshi
January 2013, 32(6):50-50
Purpose: Ksheerpaka i.e. milk used in the medicated form is the unique feature of Ayurveda. Now a day, for Ksheerpaka preparation, method stated by Sharangadhara is generally followed. Charaka has mentioned Lasuna Ksheerpaka which is prepared by different proportions than that of Sharangadhara. Though ingredients used for preparation by each method are same, variation in proportion of ingredients may alter their respective efficacies. The present study aims at pharmaceutical and analytical evaluation of Lasuna Ksheerpaka prepared by two different proportions viz. Charaka samhita (sample C) and Sharangadhara Samhita (sample S) and to hypothesize probable biotransformation during Lasuna Ksheerpaka preparation. Method: The samples were prepared according to the reference in Charaka Samhita(Chi. 5/94) and Sharangadhara Samhita (Madhyama. 1/161). The samples were evaluated by the tests like Methylene Blue Reduction (MBR), Solid non fat (SNF), specific gravity, pH, Gas Chromatography etc. Result: The results obtained from these tests indicated rapid transformations and degradation of active volatile compounds found in Garlic. The quantitative analysis of Lasuna Ksheerpaka samples done by Gas Chromatography study showed higher retention of Allin with its less destruction to further volatile Sulphur compounds in sample C (0.410 mg/gm) in comparison with sample S (0.211 mg/gm). Conclusion: The preservation of Allin to restore the medicinal properties of Garlic is the main aim of modern Pharmaceutics. The same purpose of Allin preservation and retention of medicinal properties of Garlic can be achieved by Lasuna kshirapaka prepared according to Charaka Samhita in comparison with Lasuna kshirapaka prepared according to Sharangadhara Samhita. Thus, Lasuna kshirapaka preparation according to reference of Charaka Samhita seems to be a better option within the scope of this study.
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PA02.06. Tracking the transitions in Guggulu Kalpana : An extensive review through Brihat Trayi and Laghu Trayi
Vedvati Bhapkar
January 2013, 32(6):51-51
Purpose: Guggulu Kalpana enjoys a coveted position in the arena of Ayurvedic therapeutics. Guggulu Kalpana is widely used in Charak Samhita & Sushruta Samhita and its notable collection is described in Ashtanga Sangraha. Out of laghu trayi, Sharangadhara Samhita has described Guggulu kalpas at length. Though its present form is closely related to Guti Vati Kalpana, it has not been the case always. Present study was attempted to track these transitions in Guggulu Kalpana during period of Brihat Trayi and Laghu Trayi and propose the importance of this journey in the view of current Ayurvedic pharmaceutics and therapeutics. Method: A comprehensive review of Brihat Trayi and Laghu Trayi was done. Opinions of their critics as well as contemporaries were also taken into consideration. These views were collated on the basis of current trends and researches in Guggulu Kalpana. Result: Amongst other categories, main usage of Guggulu Kalpana was seen in form of Kwatha and Guti Vati Kalpana. Though used in great deal, Brihat Trayi doesn't describe Guggulu in every respect. Different point of view regarding preparation of Guggulu Kalpana was observed in all these treatises. Various functional limitations and constant improvisations seemed to have shaped the Guggulu Kalpana in its today's form. Conclusion: Current status of Ayurvedic pharmaceutics in general and Guggulu Kalpana in particular, is greatly influenced by Sharangadhara Samhita. It mainly shows use of Guggulu in GutiVati form. The Brihat Trayi treatises, however display its use in Conjunction of Kwatha Kalpana chiefly. This paradigm shift in the pharmaceutics of Guggulu Kalpana highlights the buoyant and pliant nature of Ayurveda. The difference in choice of kalpana is explained on the basis of soluble alkaloid content and insoluble resinous gum content of Guggulu .Thus, this study is helpful to understand the progression of Ayurvedic therapeutics and prospective avenues for its advancement.
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PA02.07. Rational scientific analysis of modern lifestyle as a nidana w.s.r to viruddha ahara
BV Rashmi
January 2013, 32(6):52-52
Purpose: To understand the concept of viruddha ahara as a nidana in causation of diseases and to know its relavance in the present era. In the classics hitabhuk, mitabhuk, kshutabhuk, rhutubhuk are mentioned for maintaing the health of a person. Ahara that which vitiates dosha and which is antagonist to the dhatu in the body is known as viruddha ahara. Method: Classical literatures like bruhat trayi, laghu trayi, other texts and contemporary books are reviewed. The datas collected are analyzed scientifically with the help of contemporary science. Result: The eighteen types of viruddha ahara mentioned in the classics like desha, kala, agni, matra, etc. are understood with the help of examples like Agni viruddha In mandagni condition consuming guru snigdha ahara. In condition like dyspepsia where impairement in gastric, bile, pancreatic secretions are present, due to increased intake of mamsala ahara which are rich in amino acids and lipids impaires metabolism. Satmya viruddha Person satmya with katu ushna dravya sevana consuming increased swadu sheeta dravya. Persons habituated with rich spicy diet like pepper which causes irritation of gastric mucosa leading to increased gastric juice secretion, if increased intake of chilled soft drinks in such persons causes constriction of gastric mucosa leading to less gastric juice secretion. Avastha viruddha after nidra consuming kaphavardhka ahara like curd. After sleep basal metabolic rate of the body is reduced , curd which is rich in fats and carbohydrates requires more time for digestion. The rest types of viruddha ahara are analyzed and understood scientifically in the same manner as explained above. Conclusion: Ayurveda emphazises on nidana parivarjanameva chikitsa, understanding the nidana is prime important. Viruddha ahara affects the body metabolism and hence the concept of viruddha ahara is relevant to present era.
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PA02.08. Role of herbs in psychosomatic disorders
KVRSS Ramgopal
January 2013, 32(6):53-53
Purpose: Stress is taking toll of the health of the people in this present competitive and challenging world. Ayurvedic acharayas have realized the role of mind on the body thousands of years ago. While mentioning the etiology of almost every disease our acharyas have mentioned the psychological factors like bhaya, shoka, kroda etc along with the physiological causes. It shows the effect of mind in causation of a disease. These psychological factors like bhaya, shoka etc when become excessive and uncontrollable they lead to manasika rogas. These manasika rogas are called as psychosomatic disorders. In Ayurveda a number of herbs have been mentioned as medhya rasayanas. The herbs like brahmi, mandookaparni, shankapuspi, aswagandha, yestimadhu, guduchi etc, have been mentioned at various contexts which work in different ways to help restore the health in psychosomatic disorders.Hence the present topic the "ROLE OF HERBS IN PSYCHOSOMATIC DISORDERS" was taken up to study the mode of action of herbs mentioned in manasika rogas. Method: The drugs mentioned by the brihatrayees under the treatment of manasika rogas like unmada and apasmara are enumerated and later the properties of most frequently mentioned herbs are studied. Result: The herbs like Brahmi, Shankapuspi act by their nootropic activity and the herbs like Lashuna, Vaca etc act by their high antioxidant property. Conclusion: The drugs by our acharyas act by their rasa, guna virya and vipaka help in the elimination of aggravated dosas their by helps the body to regain the homeostasis of tridoshas.
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PA02.09. Role of surface electron microscopy (SEMEDAX) in analysis of agasti patra bhavit shuddha manashilla
Ekta Tomar
January 2013, 32(6):54-54
Purpose: SEMEDAX is a highly sophisticated analytical technique for elemental analysis of any inorganic material. It can help us to evaluate the changes which take place in inorganic material after shodhan, which can scientifically relates the thing or can help us to generate the evidence which will help to rule out the reason of various types of shodhan specifically mention in Granthas. Method: Shodhan of Manashilla was performed as described in Rasatarangani (11/113). SEMEDAX was done of both the sample of Ashuddha and Shuddha Manashilla. In SEMEDAX Coating of sample were done and then placed under scanning electron microscope. Result: SEMEDAX reveilles the presence of all elements present in Manashilla along with its atomic percentage value. There is a change in atomic percentages of all the elements after shodhan which indicate that shodhan bring changes at its atomic level which may be responsible for its biological properties. Conclusion: Oxygen, Sulfur, copper, calcium, Arsenic, Thorium was the detected elements present in Manashilla. After shodhan there is alteration in its atomic percentage value SEMEDAX revealed that percentage of arsenic decreases after shodhan whereas percentage of oxygen and calcium rose. from this we can conclude that shodhan not only remove external impurities but it bring changes to its atomic level which is responsible for its pharmacological action and may be responsible for targeting the drug to the site of action, thus SEMEDAX is a crucial tool to shows that shodhan brings elemental alteration with the help of this tool we can proof that shodhan has scientific approach and its an unavoidable procedure.
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PA02.10. A review on immunomodulator activity of some indiginious medical plants
S Brahm Dutt
January 2013, 32(6):55-55
Purpose: It has been estimated that about 6 laks infant and young children die from RSV annually, and if bacterial co infections are included this number may approach 10 laks deaths annually. More than 2 million deaths are estimated to result each year the world over as a consequence of diarrheal disease in children of under five years. This statistic shows that children are more vulnerable to infection because their immune system is less or under developed. At this age any intervention which could motivate their immune system, may prove boon to them. Ayurveda with its concept of Rasayana is holding various medicinal plants which are excellent immunomodulator and capable to reduce the morbidity status. Method: Peer review journals were searched to list all medicinal plants with immunomodulator activities, particularly acting on recurrent respiratory infection and recurrent diarrhoeal episodes. Only full texts in English were accepted for the present study. Result: Out of all researches Amalaki (Emblica officinalis), Ashwagandha(Withania somnifera), Yashtimadhu (Glycyrrhiza glabra), and Guduchi (Tinospora cordifolia) were found more potent to reduce morbidity rate. In which Amalaki is very cost effective, easily available, easily cultivated with highest immunomodulator properties. Conclusion: Recurrent respiratory tract infection and recurrent diarrhoeal episodes are major part of morbidity and Amalaki is a best option to reduce it.
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PA02.11. An insight on ayurvedic drug discovery
Yogesh Desai
January 2013, 32(6):56-56
Purpose: Every dravya have its own medicinal importance in the universe. Hence, we have to study each and every drug which is available around us. The locally available drugs are considered as best. Only few drugs are mentioned in ayurvedic textbooks but many have to be explained for their quality & applications. The research on new drugs is the need of hour in Ayurveda and we have to assess all dravyas viz. herbs, metals, minerals & animal products which are available in universe. Method: Drug research methodology is well explained in Ayurveda along with ethno & medico botanical survey. There are certain steps of research viz. the nature of dravyas, morphological characters of dravyas, place & time of collection, preservation etc and doctrine of signature or elaborate in new drug discovery. Further taste and taste threshold examination, exothermic and endothermic reactions, experimental model for assessment of vipaka and other methods of research on new drug will be discussed. This paper will discuss in detail about the ancient research method for new drugs. Result: Methodical research for new drug gives not only importance of pharmecological and clinical study but also importance to seasonal derivation, collection time and different application methods. Ancient ayurvedic drug research methodology includes from survey, pharmacognostic to clinical research. Conclusion: The oldest drug research methodology suits now also for all new drug research.
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PA02.12. Toxicity studies on shankha vati
Naveena Kodlady, BJ Patgiri, B Ravishankar
January 2013, 32(6):57-57
Purpose: Shankha Vati, a classical Ayurvedic formulation that is widely used by the practitioners of Ayurveda, contains a heavy metal i.e. Parada (mercury) and a poisonous herbal drug i.e. Vatsanabha (Aconitum chasmantum Staff.ex.Holmes) along with other ingredients. There are certain apprehensions on this formulation, mainly due to the presence of its ingredient Vatsanabha. Shankha Vati (Bhaishajya Ratnavali 10/186 - 187, also in Ayurvedic Formulary of India Part1), is one of the formulations in which Vatsanabha is used without its usual coingredient and antidote Tankana (borax). With an hypothesis that classical combination of Shankha Vati is not completely safe and there could be some adverse effects due to the presence of poisonous ingredient Vatsanabha in it, and any possible adverse effects of Shankha Vati due to the presence of Vatsanabha will be nullified by the addition of Tankana to the formulation, another modified formulation with the addition of purified Tankana equal to the quantity of Vatsanabha in the classical Shankha Vati, was also taken up for the study. Method: Acute toxicity study as per OECD Guideline 425, and Chronic toxicity study (90 days with the recovery period of 30 days) as per AYUSH170 guideline (Guidelines for preclinical safety evaluation for Ayurveda, Siddha and Unani drugs and other traditional medicines in India) were carried out. Biochemical and haematological investigations were carried out on 30th, 60th, 90th and 120th days. Histopathological study of acute chronic toxicity study were carried out. Result: Histopathological study of both acute and chronic toxicity study were also carried out. There were no toxicity related changes found in the animals treated classical Shankha Vati as well as modified Shankha Vati in both acute and chronic toxicity study. Similarly biochemical and haematological investigations also did not toxicity related changes. Conclusion: Classical formulation of Shankha Vati is completely safe and there is no need to modify the composition to make it safer.
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PA02.13. Invitro antimicrobial study of Gojihwadi kwatha ghana with special reference to upper respiratory tract infection
Prakash Jondhale, P Suresh, RP Sharma, Ekta Minghani
January 2013, 32(6):58-58
Purpose: Bhaishajya Kalpana is a specialized branch of Ayurveda which deals with the procurement, processing and right application of a drug to cure any diseases. Simply it is an art of preparing and dispensing of medicine. Gojihwadi Kwatha is a most common drug used in ailment of upper respiratory system, such as Pratishyaya, Kasa, Shwasa in day to day clinical practice.Extracts of Gojihwadi Kwatha was done with an intention to evaluate its efficacy against selected URTI (Upper respiratory tract infection) causing pathogenic microorganism. Method: Different extracts were prepared by extracting samples of Gojihwadi Kwatha Ghana were tested for their antimicrobial activity against pathogenic organisms. Result: Ghana of Gojihwadi Kwatha showed significant inhibition of various microbes related to URTI specially Pseudomonas aeruginosa, Klebsillae pneumonae and Proteus vulgaris. Hence efficacy of Gojihwadi Kwatha as mentioned in classical text is hereby scientifically validated.
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PA02.14. A review on immunomodulator activity of Yashtimadhu (Glycyrriza Glabra).
Krishan Kumar, N Rakesh Kumar
January 2013, 32(6):59-59
Purpose: Recurrent respiratory infection, diarrhoea etc. are the most common causes of morbidity in immune compromised children. Majority of children below the age of 5 years do get 7‑8 episodes of cold per year . In developing countries about 15 million children under the age of 5 years die each year. Respiratory infection account for 4 million of deaths. In India 15% of death occurs during infancy and 1‑5 years of age are due to respiratory infections. This statistic shows that children are more vulnerable to infection because their immune system is less or under developed. At this age any intervention which could motivate their immune system, may prove boon to them. Ayurveda with its concept of Rasayana is holding various medicinal plants which are excellent immunomodulator and capable to reduce the morbidity status. Method: Peer review journals were searched to list all medicinal plants with immunomodulator activities, particularly acting on recurrent respiratory infection and recurrent diarrhoeal episodes. Only full texts in English were accepted for the present study. Result: Out of all research Yashtimadhu (Glycyrrhiza glabra) was found potent to reduce morbidity rate. It is very cost effective, easily available with highest immunomodulator properties.
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PA01.01. Effect of rakthamoksha in sandhigata vata with special reference to osteoarthritis
Pouse Poulose
January 2013, 32(6):42-42
Purpose: To evaluate the effect of rakthamoksha in Sandhigata vata.There are different type of joints like Fibrous, Cartilaginous & Synovial the sandhigata vata can affect the joints.My study is to evaluate the effect of rakthamoksha in sandigata vata. Method: After poorvakarma by doing sneha and swedana a tourniquet is applied tightly 4 inches above the selected area to facilitate bleeding.Then pricking is done it's not deep.When the required amount of blood is let out the tourniquet is released. Result: Patient got relief from pain due to sandigada vata. Conclusion: It's a effective treatment that will bring quick relief of pain to sandigada vata patients.
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PA01.02. Effect of Shodhana Karma in early Psoriasis‑ A case study presentation
Umesh Sawant, Shreya Sawant
January 2013, 32(6):43-43
Purpose: To show the effect of holistic Ayurvedic Treatment in a critical disease like psoriasis in early stage. Method: A patient of known case of psoriasis (not more than 2 yrs) given systematic Ayurvedic Shodhana Karma every 3 yrs. Result: After shodhana Karma, patient got both Subjective & objective relief from Symptoms for a long duration than modern medicines. Conclusion: Pure Ayurvedic Traditional treatment can give relief from symptoms of psoriasis for a longer time without any side effect.
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PA01.03. Management of vocal cord nodule with Kanthya Gana Maha Kashaya‑ A case study
T Megha, Shreevathsa
January 2013, 32(6):44-44
Purpose: Speech with the normal voice, pitch and loudness is necessary for any individual. By excessive or misusing of vocal cord leads to a nodule formation which further hampers the voice. In contemporary view the only method for this condition is voice therapy and if the therapy is not favouring then surgery is advised. hence its an opportunity to bring the ayurvedic method of treatment for this condition and hence forth the drug has been selected for a case study. Method: Intervention with the kashaya for 1 month with dose of 1tsp A/F BD. Result: In the final results no vocal cord nodule has been seen. Conclusion: It can be concluded that the kanthya gana maha kashaya is capable in reducing the nodule by its lekhana and deepana property in it.
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PA03.01. A clinical study on the management of vicharchika (eczema) by brihat haridrakhanda and lepa of arka taila in children
TU Arya, U Shailaja Rao
January 2013, 32(6):70-70
  1. To find out an easily available and considerably low cost, safe and effective remedy for the treatment of Vicharchika. 2. Clinical assessment of the efficiency of Brihat haridrakhanda orally & Arka taila as per in the management of Dry eczema. 3. To evaluate the clinical efficacy of Brihat haridrakhanda ora lly & Arka taila as per in the management of Wet eczema. 4. To compare the effect of Brihat haridrakhanda orally & Arka taila on Dry & wet Eczema.
Method: 30 cases of Vicharchika were selected randomly from OPD and IPD of Kaumarabhritya S.D.M. College of Ayurveda and Hospital, Hassan.Study is carried out in two groups, each containing 15 patients.Dry group Patient with dry lesion (Shushka Vicharchika). Wet group Patient with wet lesion. (Sravi Vicharchika)Both groups had given Brihat Haridrakhanda orally & Lepa of Arka Taila for 1month along with follow up for 1 month and results observed. Dose:a) Brihat Haridrakhand: 5gms mixed with lukewarm milk; twice daily half an hour before food.b) Arkataila: required quantity for external application. Result: The study showed there was statistically significant improvement in Kandu (83.33 %),Pidaka (58%),Vaivarnata (55 %) Rookshata (66.66 %) & number of patches (50%) in dry group & there was statistically significant improvement in Kandu (63.63 %), Pidaka (40 %), Vaivarnata (59.26 %), Srava (60 %) & number of patches (50%) in wet groupThe study concluded that there was better improvement in the Dry group in reduction of Kandu, Pidaka, Daha, & Number of patches compares to wet group while in wet group there was better improvement seen in reduction of Vaivarnata & Area of patch compare to Dry group. Conclusion: Local application and oral medication is more effective. The drugs are having the property Kaphahara, Kandughna, Sravahara & helps in reduction of Rookshata. Brihat Haridrakhanda is sweet and easily palatable.
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PA03.02. The effect of bhumyamalaki (Phyllanthus Niruri) in balatisara with special reference to viral diarrhea
Nabisab Kamatnur, Ajay Chawan
January 2013, 32(6):71-71
Purpose: Balatisara is one of the commonest diseases in developing countries like India. There are 5 billion episodes of diarrhea every year out of which 3.5 million children die. Bhumyamalaki is known for its antiviral activity, 90 % of infantile diarrheas are due to some enteroviruses. Therefore the present research work was planned to evaluate the effect of Bhumyamalaki syrup. Method: The present study was conducted on 30children presenting with viral diarrhea in between the age group of 1 to 10 years.The patients were selected from S.D.M.C.A & Hospital, Hassan.They were divided into two groups with 15 children in each group, viz. Group B (Bhumyamalaki syrup) and Group S (sugar syrup as placebo). The syrup was given in a dose of 5ml and 10ml for the age group 1to 5 years and 5 to 10 years four times a day for 7 days respectively. The cases were recorded according to the case proforma prepared for the study and observations were graded according to the gradation chart prepared. Result: Bhumyamalaki Syrup provided significant relief in the symptoms of viral diarrhea such as Malavega (73.19%), consistency (67.48%), fever (88.49%),vomiting (89.24%), abdominal pain (89.68%), loss of appetite (95%) and dehydration (95.89%). In this group, 73.33% and 26.67% patients showed marked and moderate improvements respectively. Sugar syrup provided relief in the symptoms such as Malavega (36.84%), Consistency (45.39%), Fever (67.14%), Vomiting (74.27%), Abdominal Pain (75.90%), Appetite (74%) and Dehydration (85.71%).In this group, 53.33% and 46.67% patients showed moderate and mild improvements respectively. Conclusion: Bhumyamalaki Syrup provided better relief in comparison to sugar syrup in the symptoms of Mala Vega, consistency, fever, vomiting, abdominal pain, appetite and dehydration.
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PA03.03. Effect of manjishtadi lepa in management of ankle sprain
S Suraj Patil, P Hemantha Kumar
January 2013, 32(6):72-72
Purpose: To evaluate the effect of Manjisthadi Lepa in the Management of Ankle Sprain. To compare the effectiveness of Sheeta and Ushna Manjisthadi Lepa on Ankle Sprain. Method: Cases presenting with classical signs and symptoms of Ankle Sprain were selected from the outpatient and in patient department of Shalya Tantra. They were randomly allocated into two groups with 20 patients. Group - A / Sheeta Group- Sheeta Manjishtadi Lepa. Group - B / Ushna Group- Sheeta Manjishtadi Lepa. Lepa was applied twice daily for one week duration and daily assessment of the clinical parameters was done according to the proforma and weekly follow up for four weeks Result: Duration of one week treatment has provided significant relief with a value of 88.23% in pain, 85.71% in tenderness, 75% in swelling, 100% in loss of function and 100% in discoloration. 100% result is obtained in the movements of joint as dorsiflexion, plantarflexion, adduction, abduction, inversion and eversion after the application of Sheeta Manjisthadi Lepa. After the application of Ushna Manjisthadi Lepa pain reduced by 91.17%, tenderness by 86.%, swelling by 76.4%, loss of function by, discoloration and movements of the joints by 100% with P< 0.001 in both groups. On the second follow up only 100% relief was noted in all the parameters in both the groups. Conclusion: Group A / Sheeta group patients showed better improvement in the initial days of treatment i.e. in conditions of Acute Ankle Sprain, where as in Group B/Ushna group showed better improvement in later stage i.e. in Chronic Ankle Sprain. Complete remission was seen in 75% of patients, marked improvement in 17.5%, moderate improvement in 7% and no patient showed unchanged results after one week treatment.
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PA03.04. Clinical study of trikatu thaila nasya in the management of kaphaja sirasoola (maxillary sinusitis)
K Sivabalaji
January 2013, 32(6):73-73
Purpose: Kaphaja Shiras Shoola is one among the types of Shirorogas. It can be correlated to the diseases of maxillary sinusitis. It is one of the commonly found diseases in day to day clinical practice. The symptoms of Kaphaja Shiras Shoola include mild / moderate head ache, heaviness of head, nasal discharge and nasal obstruction. Objectives of the present study were to get a solution to kaphaja sirasoola by evaluating the efficacy of trikatu thaila nasya in the management of kaphaja sirasoola. Method: 20 patients fulfilling the inclusion criteria of Kaphaja Sirasoola were randomly selected from the OPD and IPD of S.D.M College of Ayurveda & Hospital, Hassan. Nasya was given with 8 drops of medicine in each nostril early in the morning on empty stomach for seven days. Follow up was done for the period of 2 months. Clinical sign and symptoms were given on the basis of self formulated scoring scale. The result having 'p' value less than <0.05 were considered as statistically significant in this study. Result: Overall effect of therapies after the course of treatment showed complete remission in 10%, marked improvement in 74%, moderate improvement in 11 % and mild relief in 5 % of patients. Conclusion: Trikatu thaila nasya has significant effect in the management of kaphaja sirasoola. Reduction in clinical symptoms was appreciated after nasya is proved statistically significant.
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PA03.05. Masha taila as a preventive measure in gulpha marma injuries.
Rajani Dhaded, BG Kulkarni
January 2013, 32(6):74-74
Purpose: In Basketball game Gulpha Marma injuries are common. Wrong landing causes inflammation & tearing of ligament resulting into sprain.Prevention can be carried out by protective wears like Ankelet,crape bandge which gives temporary recovery. Assessment and evaluation of the application of Masha Taila as a Snehana and Avagaha Sweda as a preventive measure for Gulpha Marma injuries. Method: 30 players with Normal ankle joint (Group A) & 30 players with Ankle sprain (1st degree) of Basketball players (Group B) were taken with age group 13 to 25 yrs. Goniometer to measure Range of motion (R.O.M.), pain analog scale for pain gradation. Result: Group A and B were compared with their control groups.The statistical result for normal dorsiflexion was 0.0007 degree, plantar flexion 0.001 degree, dorsi flexion of ankle sprain players 0.002 degree, plantar flexion 0.03 degree.The measurement of ROM of all players increased by 510 times indicating increased joint flexibility, based on ROM Mash taila proved to be a preventive measure. Pain analog scale for group B players indicated moderate pain at 0 day,reduced by 50% on 15th day and completely reduced on 30th day. Conclusion: "Prevention is better than cure".As a preventive aspect the application of Masha Taila in normal ankle joint as Snehan & Swedan with warm water increases flexibility of joint and muscle strength. In sprained joint the same Taila application relives pain and regains its movements, this recovery and strength of joints happens because of reduce adhesion & influence the direction of new collage fibres in the healing process. It eliminates toxic accumulation from secondary muscle spasm.These Marma being the vital points must be prevented by applying Snehan & Swedan before starting the game just as warm up.
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PA03.06. Swertiamarin A novel lead to antidepressants
K Dharaniyambigai, VA Doss
January 2013, 32(6):75-75
Purpose: Conventional medicine says depression is a psychological disorder due to imbalance of neurotransmitters in the brain and that which thereby focuses on managing depression rather than curing it. Contrary, ayurveda treats depression in a gentle, natural and effective way. Identification of ligands and phytochemicals that are responsible for antidepressant activity in plants are necessary in order to develop efficient drugs that are rapid and effective naturally without side effects even in acute administration. Method: Swertiamarin an unique phytochemical of the Gentianaceae family is a secoiridoid glucoside, is purified and quantified from sources namely Enicostemma littorale, Swertia chirata, S.japonica and S.angustifolia using HPLC with ethyl acetate: methanol: water (7.7:2.0:0.5) solvent systems. This purified phytochemical, hypothesized to possess antidepressant activity is then subjected to structure elucidation using mass spectrophotometer and Xray diffraction studies and proceeded with homology modeling for docking the swertiamarin with imipramine, citalopram, fluoxetine and venlafaxine receptors (antidepressant sites). The purified swertiamarin is further subjected to clinical and biochemical parameter analysis thereby analysing its potential to treat the depression induced in animals (group study) comparison with the standard allopathic antidepressants. Result: The source rich in swertiamarin can be determined using HPLC and are considered for further clinical and therapeutic parameters. The comparative structure elucidation of swertiamarin with MS and Xray diffraction analysis from various sources under study can predict the diversity of the compound which can serve as basis for functional analysis. The modeling and docking studies reveal the interactions of swertiamarin with its receptors (site of action) whose understanding can aid in revealing its mechanism as an antidepressant. Besides these, the clinical trials in shows the efficiency of swertiamarin as an antidepressant when compared to other drugs. Conclusion: This study can provide basis for improvement of ayurvedic antidepressants through phytochemical and clinical research which can aid gentler and quick treatment that can result from low and acute doses.
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PA03.07. A clinical comparative study of Matra Vasti and Vaitran Vasti in the treatment of Gridhrasi w.s.r to Sciatica
Charu Gupta, Arvind Chaudhary
January 2013, 32(6):76-76
Purpose: Sciatica is a vata dominant vikar and vasti is a vata dominant chikitsa. Matra Vasti is a nirapad vasti and can be given in any condition without following the ahara and vihara, then what is need for Vaitran Vasti? So, here an effort was made to study the effect of Matra vasti and Vaitran Vasti separately in the treatment of Grihdrasi. Method: 30 patients were randomly selected from the OPD and IPD of Kayachikitsa Department of Ayurvedic Medical College,Davanagere, Karnataka and were separated in two groups of 15 each,and a study was conducted.Along with vasti chikitsa oral medication was also given.Ekangvir rasa in the dose of 500mg B.D and Lashunadi vati in the dose of 2 tabs. B.D. Result: Results were evaluated on the basis of symptoms of types of Gridhrasi i.e vataja and vatakaphaja as mentioned in Charak Samhita which showed marked improvement in all the symptoms. A Ttest was performed which gave a significant result of (P<.001). Results were also seen on the basis of International Scale which resulted in improvement in functional ability and reduction in functional disability. Conclusion: It can be said that Vasti plays an important role in the treatment of Grihdrasi. In Vataja type Matra Vasti had played an supreme role as it helps in treating degenerative pathology and in Vatakaphaja type Vaitran Vasti had played a first rate role as it helps in treating inflammatory pathology.
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PA03.08. A clinical study on the effect of yoga in Udavartini Vyapad w.s.r. to primary dysmenorrhoea
P Udayakala, R Aditi Bana
January 2013, 32(6):77-77
Purpose: 1. To evaluate the role of yoga in the prevention of Udavarthini Yonivyapad 2. To observe other relative benefits after the intervention with yoga. Method: It is a clinical study with a pretest and posttest design in three groups, each group comprising of 10 patients. Group A (medicine group) Group B (yoga group) Group C (yoga + medicine group) The yoga practice consisted of selected yogasanas, pranayama techniques and meditation with 2030 minutes duration for a period of 3 months with monthly assessment of improvement. Result: Yoga practice has shown good results in reducing the intensity of pain by 38.24%. The other benefits observed with yoga practice were on regularizing the menstrual cycle by 43.75%. Associated symptoms of primary dysmenorrhoea got reduced by 57.14% and the premenstrual syndrome by 71.43%. Conclusion: Pain was reduced markedly in yoga group when compaired to the medicine group and yoga+medicine group. The results are suggesting that efficacy in yoga group got increased in every follow up, indicating the need for continuous practice. Yoga practice regularizes the menstural cycle and also decreases the intensity of premenstural symptoms.
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PA03.09. The role of vakshuddhikara churna in management of stuttering
R Sharashchandra, Prasad Bamne, Shrinidhi Acharya, U Shailaja Rao
January 2013, 32(6):78-78
Purpose: Speech development is a critical barometer of both cognitive and emotional development. Language development occurs most rapidly between 2 to 5 years of age. During this period of learning of speech, usually child begins repetition of consonants, often followed by repetition of words. If this condition continues then child suffers from disability of speech. Modern literature classifies stuttering as a dysfluency type of speech disorder &it can lead into disability in later ages. The present study was aimed to see the efficacy of Vakshuddhikara Churna in Management of Stuttering. Method: 30 children belonging to 5 to 12 years of age suffering from Stuttering were selected randomly. Vakshuddhikara Churna in the dose of 2 gms is applied over tongue with Madhuin morning and night for 2 months. Follow up was taken in interval of 15 days. Assessment is made by Screening, Speech Sampling and improvement in clinical features. The Stuttering Severity Index (SSI) was considered for assessment. Result: Assessment was done before and after the treatment using statistical tests on different parameters. During the study it was found that Repetition and Prolongation were the two major symptoms along with Silent Pauses. Vakshuddhikara Churna provided significant relief in the stuttering severity Index (37.14%), in reciting the days of week (37.80%), counting numbers (46.20%), monosyllables (50%), bisyllables (70%), prolongations (42.045), repetition (43.34%), hesitation (38.13%), pause (39.87%) and hard contacts (43.73%) Conclusion: Vakshuddhikara Churna provided significant relief in the main Assessment i.eStuttering Severity Index. Also provided significant relief in the symptoms of Stuttering such as Prolongations, Repetition and Hesitation
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PA03.10. A comparative study on Tailabindhu Muthra Pareeksha w.s.r Mrutpatra and Kachapatra
Devi Nair
January 2013, 32(6):79-79
Purpose: Investigations play a major role in diagnosis of any disease. Even in Ayurveda literature various examination methods are explained, even then we are completely depending on modern parameters due to lack of proper understanding and explanations available in our texts. So need of the hour is to evaluate the practicability of Tailabindhu Mutra Pareeksha with standardisation according to classical text so as to make it relevant in the present era and successfully prove its importance. Method: A comparative experimental clinical study on Tailabindhu Mutra Pareeksha standardised as per classical reference was conducted on 35 IPD patients of SDMCAHH with varied diagnosis including Madhumeha, Thamakashwasa, Kamala,Pakshaghata etc. Before sunrise mid stream urine of 35 patients were collected and analysed under sunlight through Tailabindhu Mutra Pareeksha standardised apparatus. Urine samples of individual patients were taken in Mrutpatra and Kachapatra respectively and simultaneously Tailabindhu was dropped and changes were observed for change in shape and movement was analysed accordingly in the background of Ayurvedic literature and modern scientific knowledge taking into consideration various lab investigation and documentation was done along with photographs. Result: Experiment was done simultaneously in Mrutpatra and Kachapatra for the mid stream urine sample collected from 35 patients and both showed noticeable change with close correlation to the modern clinical prognosis. In specific cases the changes shown by standardised test of Tailabindhu Mutra Pareeksha in Mrutpatra seemed to be more precise than the standardised test done with Kachapatra. Conclusion: A method is designed to practically utilize Tailabindhu Mutra Pareeksha fulfilling basic standards explained in text.Out of 35 samples done a variation was observed in Mrutpatra and Kachapatra in movement and shape of Taila in Urine with Mrutpatra giving a more accurate result shows a need in giving emphasis to the texture of the vessel used in Tailabindhu Mutra Pareeksha
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PA02.15. Validation of ayurvedic concept of anthropometry and clinical evaluation of efficacy of "Suktyadi Yog" as a calcium supplementation in children
S Vinod Kumar, N Rakesh Kumar
January 2013, 32(6):60-60
Purpose: The present study aims to validate the ayurvedic anthropometical parameter for assessment of proper growth & devlopment and also to identify any disease linkage. For proper bony growth adequate calcium supplement is necessary. Evaluation of role of an ayurvedic compound containing calcium preparation needed therefore included in the second phase of the study. In calcium deficiency Ayurvedic Managment "Suktyadi Yog" may be useful. It is a rich source of calcium and have deepaniya drugs. Deepaniya drugs is useful for absorption of calcium. Method: Validations of Ayurvedic Sharir pramana on the basis of modern concept (Parameters) in children and Peer review journals were searched to list content of "Suktyadi yog" with calcium supplementation activities, particularly acting in calcium deficient and healthy children. Result: Result of the study show Sharir praman of children found almost equal to as explained in ayurvedic texts. Out of all research Sukti bhasma, Godanti bhasma, yasad bhasma and Trikatu was found potent to reduce Calcium deficiency. It is very cost effective, easily available with highest calcium supplementation properties. Conclusion: Calcium deficiency is a major problem in children and "Suktyadi yog" is a best option to reduce it.
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PA02.16. Identification of the authentic species of Prsniparni using etymological analysis,microscopical and phytochemical studies.
S Aparna
January 2013, 32(6):61-61
Purpose: The Ayurvedic herbs are in high demand in the present day market. Many species are used in the name of authentic drugs, along with this substitute and adulterant drugs are also in use. There is some controversy in the identification of the drugs. Many synonyms mentioned in the classical texts and lexicons describing about the plant is one of the causes of the controversy in identification. Prsniparni is one such herb among the Dasamulas which is used as different species based on the regional availability. Uraria picta is used in the northern parts of the country where as Psuedarthria viscida is used in the southern regions. Uraria lagopoidiodes and Desmodium gangeticum are also used in the name of Prsniparni. The aim of the study was to develop quality standards for authentic, substitute and adulterant species using etymological analysis, microscopy, histochemistry and phytochemistry. Method: Etymological analysis was carried out to correlate the synonyms mentioned in Ayurvedic texts with the botanical descriptions of plant candidates. The synonym that matches with the botanical description was given '1' point and where it does not match was given '0'. Anatomical, histological, powder microscopy and histochemical studies were conducted. Physicochemical, phytochemical and HPTLC analysis were done to develop quality standards for the species traded as Prsniparni. Result: The synonyms mainly describe about morphology, inflorescence and leaves. The name Prsniparni describes it is a small plant with markings on the leaves. Many synonyms correlate with the U.picta. Microscopical studies and HPTLC studies showed similarities with U. picta and U.lagopoidiodes. Similarities on anatomical, HPTLC finger prints were developed to authenticate the species. Conclusion: U. picta scores the maximum number of points followed by U. lagopoidiodes., D. gangeticum is Salaparni and P.viscida scores the least points so it cannot be considered as authentic. So the most authentic drug of Prsniparni is Uraria picta Linn.
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PA02.17. Viruddha Aahara‑ Trisutra
Manisha Dunghav
January 2013, 32(6):62-62
Purpose: In todays fast life every one wants to save his time and energy. As a result one has to take help of fast food to subside the hunger . Then the commonly eatables like vada pav ,fruit salad, different kinds of milk shakes etc. can be eaten by the people. Here Ayurved can be work as a diet guide. Equaly ayurved focuses on viruddha aahar which produced the vitiation of all doshas.Whatever we eat that affects on our body as well as mind also. So we should eat healthy food which will enhance our health.And avoid to eat viruddha aahar as a preventive measures of the diseases. Avoidance of intake of viruddha aahar play key role in the prevention of diseases. Method: Ayurvedic text ‑Charak Samhita, Ashtang Hriday. Result: Purgation,emesis,antidotes and prophylaxis‑ these four cure the diseases caused /to be caused by the intake of unwholesome drugs and diets. Frequent intake of combination of incompatible food leads in to toxins. Conclusion: Frequent intake of Viruddha aahara act as a visha or poison which leads to aggravation of all doshas .
  1. The recommended therapy for viruddhaashanjanya vyadi is eliminative(Shodhana) , Palliative(Shamana) & Apunarbhava Chikitsa .
  2. Effects of viruddha aahar can be classified in to immediate (AaSaukarI ) and delayed effects( icarkarI) which may be modified in the form of symptoms or diseases.
  3. Avoidance of Viruddha aahara plays key role in the prevention of diseases.
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PA02.18. Phytochemical screening and antioxidant activity of Amrutha Choornam
K Asha Maniyan, A Sindhu
January 2013, 32(6):63-63
Purpose: Background of the study: Diabetes mellitus is a common metabolic disorder characterized by high levels of blood glucose. Many studies have proven that oxidative stress plays an important role in Diabetes Mellitus. The etiology of oxidative stress in diabetes arises from excessive oxygen radical production from auto oxidation of glucose and glycosylation of protein, glycation of antioxidative enzymes. Aim: The present study evaluates Amrutha Choornam for its phytochemical and antioxidant property Method: The Sample was collected from The Arya vaidya pharmacy (Coimbatore) Ltd, Factory, Kanjikode. The preliminary phytochemical screening was determined using the methods by Harborne and the antioxidant activity was estimated by DPPH (2'2‑diphenyl‑1‑picryl hydrazine) radical scavenging activity. Result: The three extracts of Amrutha choornam namely hexane, ethyl acetate and methanol were subjected to preliminary phytochemical screening. On comparing the results, the phytoconstituents were found to be higher in methanolic extract. Carbohydrates, phenols, tannins, Flavanoids, terpenoids, anthraquinones, and saponins were identified in the methanolic extract. In hexane extract carbohydrate, tannins, terpenoids Anthraquinones were present and in ethyl acetate extract showed the presence of carbohydrate, tannins, and terpenoids. The radical scavenging activity was found to be higher in the Ethyl acetate extract (7.9μg/ml). The methanol extract possessed a better activity with an effective concentration of (9.8μg/ml). The less activity was found in hexane extract (2800μg/ml). Conclusion: The protective and preventive action of Amrutha Choornam in Diabetes mellitus could be due to its pronounced antioxidant activity. The potent phytochemicals in the formulation may be associated with its antidiabetic property.
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PA02.19. Prospects of commercial utilization of water extracted Curcuma longa
MR Rajalakshmy, A Sindhu
January 2013, 32(6):64-64
Purpose: Background of the study: Water extraction is a major activity in the processing of formulations such as Kashayam, Arishtam, Medicated Oil and Lehyam. The herbal residues produced after the water extraction are mostly discarded. This study is on one such residue of a potent herb namely Curcuma longa. Curcuma longa generally known as turmeric is an important and potential drug widely used in different formulations of Ayurveda. The officinal part used is rhizome. It has been Phytochemicaly explored by different researchers .The prominent active principle in it is considered to be the phenolic compound Curcuminoids. Curcumin is the major compound in Curcuminoids. It is responsible for the yellow colour of turmeric and is practically insoluble in water. An assessment of phytochemicals in Curcuma longa rhizomes, before and after water extraction, and the fate of water insoluble compounds and Curcumin is explored in this paper. Aim: To explore bioactive principles retained with the remnants of curcuma longa rhizomes, after taking water decoctions and the scope of commercial utilization of the remnants or the active principles. Method: The samples were collected from The Arya Vaidya Pharmacy (Coimbatore) Limited. The preliminary phytochemical studies were done using the methods by Harborne and the antioxidant properties were estimated by DPPH radical scavenging activity. Result: Preliminary phytochemical studies on Curcuma longa rhizome samples before and after extraction show the presence of bioactive principles like phenols, alkaloids, flavonoids and terpenoids in both samples. The physicochemical parameters such as Alcohol extractive values, Total Ash, and Acid insoluble Ash were also compared. Thin layer chromatography was carried out for phytochemical comparison of methanolic extract of Curcuma longa before and after extraction and the profile shows comparable spots at same Rf values. The isolated Curcumin was compared with the standard Curcumin by UV‑Visible Spectroscopy and the ?max was obtained at 421nm.The yield of Curcumin obtained was 3.91%. The antioxidant study gave IC50 values for the fresh sample, extracted herb and Curcumin are obtained at concentrations 49μg/ml, 85μg/ml and 12.1μg/ml respectively. Conclusion: The present study shows that considerable amount of secondary plant metabolites are retained in the herbal residue. The presence of phenols and other secondary metabolites in the herb even after extraction suggest that they can be used either as such for the isolation of Curcumin, a natural colouring compound. Both turmeric and Curcumin has wide application in Pharmaceutical, Food and Textile industries. Usually a large amount of such extracted curcuma longa is available from Ayurvedic Industry. Scope of the present study thus can be extended further to the possible utilization of the extracted Curcuma longa.
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PA02.20. A comparative study on the total phenolic content and antioxidant property of two Ayurvedic formulations‑Indukantham gritham and Indukantham kashayam
CV Sruthi, S Vendamirtham, A Sindhu
January 2013, 32(6):65-65
Purpose: Background‑: Indukantham Gritham is a formulation referred in the text of Sahasrayogam in the context of Gritha yogam. This formulation is also used in the water extract mode for treatment purpose. Indukantham combination is a potent formulation which enhances immunity with special indication in respiratory disorders and recurring fevers. Antioxidants play a significant role in improving the immunity and thereby in combating these conditions. Phenolic compounds are the most common water soluble antioxidant compounds found in plants. Objective‑: The objective of the present work is to provide a comparison on the phytoconstituents, total phenolic content percentage and antioxidant properties of. Indukantham gritham and Indukantham Kashayam. Method: The samples were collected from The Arya Vaidya Pharmacy (Coimbatore) Limited. Qualitative phytochemical screening was carried out using the methods by Harborne. The total phenolic content percentage of these two modes were determined using Folin‑ciocalteu's method and the antioxidant activities were estimated by DPPH (2,2‑DiPhenyl‑1‑Picryl Hydrazine) radical scavenging activity. Result: Indukantham gritham showed the presence of carbohydrates, phenols, terpenoids and steroids, whereas Indukantham Kashayam showed the presence of carbohydrates, phenols, saponins. Indukantham Kashayam exhibited higher phenolic content and antioxidant activity (% TPC‑11.91%,IC50‑0.10mg/ml) when compared to Indukantham gritham (0.03%, IC50‑106mg/ml). Conclusion: The higher phenolic content of Kashayam may be due to the water soluble nature of phenols which in turn imparts higher antioxidant activity. The extraction of fat soluble components along with water soluble components may be a reason for the higher number of phytoconstituents in gritham. The comparative study explores the difference in phytoconstituents and antioxidant properties of the Indukantham combination when formulated in two different modes.
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PA02.21. Stability study in ayurvedic products
PT Neeraj, A Sindhu
January 2013, 32(6):66-66
Purpose: The objective of stability study as per ICH is to provide evidence on how the quality of a drug substance or drug product varies with time under the influence of a variety of environmental factors such as temperature, humidity, and light, and to establish a retest period for the drug substance or a shelf life for the drug product and recommended storage conditions. Stability test is important not only in the process of product development ,but also to assess the quality of existing products over a period of time .In the scenario of ayurveda ,very little data is available regarding structured stability studies. It is also a tool to assess the life cycle of a product, and thereby derive its expiry period .It is an inevitable element in the documents related to the registration of ayurvedic products in other countries .When the ayurvedic products are subjected to stability studies ,the dossier of an ayurvedic product becomes more scientific and acceptable. Method: Types of stability studies 1.Long‑term studies : The long‑term testing or real‑time testing refer to conditions under which the product will remain stable for the specified period. 2. Accelerated studies : The accelerated testing conditions are at least 15 °C higher than the long‑term study conditions and are intended to increase the rate at which degradation reactions take place thus revealing quality changes at an early stage Globally climatic zones are divided into 4 for stability study and the storage conditions for the climatic zones are as follows. for climate zones I and II Temperature Relative humidity Long‑term studies 25 °C ??2 °C 60 % ??5 % Intermediate conditions 30 °C ??2 °C 65 % ??5 % Accelerated studies 40 °C ??2 °C 75 % ??5 % for climate zones III and IV Long‑term studies 30 °C ??2 °C 65 % ??5 % Accelerated studies 40 °C ??2 °C 75 % ??5 % Result: A structured stability study enables to determine the shelf life of the product and thereby derive at its expiry period ,most suitable storage and transport conditions. Conclusion: The paper provides a brief description on the requirement of stability testing, types of stability tests, the determination of transporting conditions based on stability data, the procedures and guide lines of stability study and the extrapolation of the generated data.
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PA02.22. Hypolipidemic effect of different coconut oil extracts of vyosakatvivaradi formulation in wistar rats.
Anita Mahapatra, Sudhir Rajurkar, Sujith Eranezhath, Ram Manohar
January 2013, 32(6):67-67
Purpose: To study the preventive and therapeutic Hypolipidemic effect of different coconut oil extracts of Vyosakatvivaradi formulation. Method: High fat diet was fed for 21 days to induce Hyperlipidemia. 110 weanling wistar rats randomly divided in to Eleven groups, four in treatment, four in preventive group, two control and one standarad group. Four test drugs - 1. VCO (virgin coconut oil) + HERBS, 2. TCO (Traditional coconut oil) + HERBS, 3. CCO (Commercial coconut oil) + HERBS, 4. TCO + Coconut Milk + HERBS were administered at the dose rate of 0.06ml tid orally for 28 days in treatment group and 28 days in preventive group from the day one of experiment and the results were compared with Simvastatin 10 mg. All the animals were anesthetized using anesthetic ether and pooled blood samples from each group were collected on day Zero, day 21st and on termination day i.e. day 28th after start of actual treatment. Result: Animals in all groups did not reveal any change in their behavior or visible adverse reaction throughout the experimental period. Statistically significant reduction in mean triglyceride values in test drug -4 animals revealed preventive. Statistically significant reduction in the mean cholesterol level (mg/dl) was observed in test drug -4 animals. Statistically significant increase in the mean HDL level 5% level of significance was observed in preventive dose of test drug 3. Microscopic observations of liver, kidney and aorta revealed no significant change. Conclusion: The medicated oil "CCO + HERBS" and TCO + Coconut Milk + HERBS" showed encouraging therapeutic and preventive effects on hyperlipidemia. However, the oil "TCO + Coconut Milk + HERBS" is observed to be better than the oil CCO + HERBS. Though the oils "VCO + HERBS" and "TCO + HERBS" exhibited moderate hypolipidemic action.
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PA02.23. Conventional role of kastaushadi in conservative, pre, peri and post operative management of malignancy
Rakesh Kumar, Rajasekhar Chinta
January 2013, 32(6):68-68
Purpose: To notify the Significance of kastaushadi in conservative, pre, peri and post operative management of malignancy. Method: Malignancy is the tendency of a medical condition, neoplasms, especially solid and hematological tumors, to become progressively worse and result in death. It is a global problem with an estimated incidence of 10 million new cases per year. Mutations and variations in Cell cycle is the main contributory factor. Current trends of using Vinca rosea, Podophyllum peltatum etc.,are showing remarkable results. Apart from already established kastaushadi, there are many other folklore kastaushadi, which need to be enlightened to treat malignancies, very effectively by their anti cancerous and anti oxidant properties. kastaushadi plays a similar important role even in recurrent and drug resistant conditions which are major limitations in the treatment of cancer. This paper also attempts to compile other anticancerous drugs. Result: Above review high lightens, understanding the samprapti at the earliest, to initiate the treatment. We can overcome the development of drug resistance and recurrence by combining various folklore kastaushadi and also treat perioperative condition which is equally important. Conclusion: The insight is drastically changed towards the search of kastaushadi and its active ingredients, in respect to promising results shown by Vinca rosea, Podophyllum peltatum and such other drugs. There are many folklore kastaushadi having anti malignant actions which need to be globalized and practiced.
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PA02.24. Importance of microscopic techniques for the identification/authentication of herbal medicines
Nini , Deepthi Mohan, B Sajini Krishnadas, KV Jyothi
January 2013, 32(6):69-69
Acceptance of Ayurveda is increasing in the society because of disclosure of its strong fundamental concepts and holistic approach. As a result, demand of Ayurvedic medicines are increasing day by day which results in the unprecedented requirement and depletion of raw materials, especially those of herbal origin. This depletion of herbs along with ignorance of herbal drug collectors from wild sources causes adulteration of drugs. Misinterpretation of Sanskrit slokas from classical texts also plays an important role. Adulteration of raw materials adversely affects the safety and efficacy of Ayurvedic preparations. Therefore standardization and documentation is essential to ensure the genunity of ayurvedic drugs. Identification and Authentication of medicinal plants are normally done by different methods like organoleptic, macroscopic, microscopic and chemical characters. Among them, microscopic techniques are one of the most important methods. The present work reveals the various microscopic characters to determine their authentication, genuity etc.
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PA03.11. Evaluation of socioeconomic status and other factors with special reference to cervical cancer A survey based study
Aruna Panwar
January 2013, 32(6):80-80
Purpose: Cervical cancer is cancer that starts in the cervix, the lower part of the uterus (womb) that opens at the top of the vagina.It is the third most common type of cancer in women. Cervical cancers start in the cells on the surface of the cervix. Most cervical cancers are from squamous cells. It starts as a precancerous condition called dysplasia. This precancerous condition can be detected by a Pap smear and is 100% treatable. It can take years for precancerous changes to turn into cervical cancer. The Papanicolaou test (also called Pap smear, Pap test, cervical smear, or smear test) is a screening test used to detect potentially precancerous and cancerous processes in the endocervical canal (transformation zone) of the female reproductive system.The test aims to detect potentially precancerous changes (called cervical intraepithelial neoplasia (CIN) or cervical dysplasia), which are usually caused by sexually transmitted human papillomaviruses. The present study was planned in the direction to evaluate. Method: In the present work, overall 50 patients of age group between 2050 yrs were selected to study their abnormal pap smear reports in relation to socioeconomic status, smoking, parity, and oral contraceptive and their relationship with abnormal cellular changes. So the patients were randomly selected for Pap smear from IPD or OPD of prasuti tantra and stri roga department of sdmca Hassan. Result: Out of 50 patients,10 patients belongs to higher class,20 patients belongs to middle class,10 patients belongs lower middle class and 10 patients belongs to lower class. Conclusion: Cervical cancer is ranked as the most frequent cancer in women in India. India has a population of approximately 365.71 million women above 15 years of age, who are at risk of developing cervical cancer. Getting regular Pap smears can help detect precancerous changes, which can be treated before they turn into cervical cancer. Pap smears effectively spot such changes, but they must be done regularly.Middle class women are more prone to this disease.PREVENTION IS BETTER THAN CURE.
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PA03.12. Role of stonvil capsule with varunadi kwath in renal & ureteric calculi
Dnyaneshwar Khandare
January 2013, 32(6):81-81
Purpose: Now a day's Renal & Ureteric calculi is very common problem in our society. In this patient experiences so much Renal pain, Ureteric colic, Haematuria, Recurrent UTI & they disturbed his daily routine work. Modern Medicines have limitations to treat it & advised Surgery to many patients. A poor & middle class patient was not tolerating surgical expenses. And there were chances of recurrences also. So I thought to use combinations to dissolve renal & Ureteric calculi and cure patients. Method: I had chosen Stonvil Capsule (Phyto Pharma) & Varunadi Kwath. Stonvil Capsule contains multiple ayurvedic drugs. I gave one Stonvil capsule with 10ml Varunadi Kwath three times a day. Before & after treatment I advised USG, Xray. Result: This Clinical study is done on 20 patients in K.G.Mittal Hospital. After starting treatment patient had relieves renal pain, Ureteric colic, Haematuria, Recurrent UTI within 1 to 4 days. Also relieves Burning Micturation & them able to do their daily routine work. This treatment was also effective in gall bladder calculi. After every 3 months advised to do USG. In some patients calculi disappeared (dissolved) after 3 months. But In some patients calculi took 6 months or more periods to dissolve. After dissolved the calculi, 1 month treatment also given for the nonrecurrence. Calculi didn't recur after treatment. Multiple calculi in two patients also dissolved by this treatment. Conclusion: Over all study the patients cured from renal & Ureteric calculi. Patient had relieved Renal pain, Ureteric colic, Haematuria, Recurrent UTI within 1 to 4 days. Also relieved Burning Micturation. Calculi dissolved & flushed out through urethra & didn't recur. Calculi disappeared in after treatment USG. Patients having multiple calculi didn't need surgery.
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PA03.13. Effect of triphaladi rasayana along with yoga therapy on low grade non hodgkins lymphoma and resistant intermediate and high grade non hodgkins lymphoma
MS Surya Soumya, TP Sarasa
January 2013, 32(6):82-82
  1. To find out the effect of Thriphaladi Rasayana along with Yoga Therapy on low grade Non Hodgkins Lymphoma and resistant intermediate and high grade NonHodgkins Lymphoma. 2. To apply a less costly, less morbid, well accepted method of treatment on NHL. 3.To find a simple method to increase the immunity. 4.To try a drug which is easy to prepare
Method: Purposive sampling technique was used for the study. Sample of 30 patients age range 25 75 years with histologicaly proven NonHodgkins lymphoma, attending the M.O.I.O.P of the regional cancer centre during a period of 18 months.Groups1) Low grade NonHodgkins Lymphoma 2) Resistant intermediate &High grade NonHodgkins lymphoma (failed chemotherapy) were taken. Procedure : 2 groups were given Triphaladhi Rasayana (15 grams of powder with ghee and honey) twice dailymorning& at bed time with milk as anupana for period of 1month along with selected yoga asanas and niyama Result: Symptoms included were fever, night sweats, weight loss, lymph nodes enlargement , splenomegaly, and hepatomegaly.In low grade symptom relief was noted in almost all cases. Lymph node changes notedLow grade5 2% (complete remission), 38% (partial remission), 10% (no change), intermediate35% (CR), 52% (PR) & 13% (NC), High grade67% (CR), 33%(PR). Hepatomegaly changes :ve in low grade92.86%, intermediate 90.9% & high grade100%. Splenomegaly changes :ve in low grade92.86%, intermediate72.72% & high grade80% Over all remission status of 30 patientscomplete remission30%, partial remission 30% & no change30% Conclusion: Thriphaladirasayana along with Yoga therapy is very effective in Low grade NonHodgkins lymphoma and resistant intermediate and high grade Non hodgkins Lymphoma
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PA03.14. Antidiabetic and antioxidant potential of Chlorophytum borivillianum (Safed musli) in type 2 diabetics
P Gayathri, S Saroja
January 2013, 32(6):83-83
Purpose: Chlorophytum borivillianum (Safed musli), is a medicinal plant with enormous medicinal properties and is celebrated as Dhivya Aushad in Ayurveda. The present study was to evaluate the antidiabetic and antioxidant potential of the tuber in Type 2 diabetics. Method: The subjects of the study were divided into four groups (Group 1: Nondiabetic control Group 2: Nondiabetic control + C. borivillianum; Group 3: Diabetics + C.borivillianum; Group 4: Diabetics + Glibenclamide) of ten individuals each. The tuber of Chlorophytum borivillianum was administered to Group 2, 3 and 4 subjects for a period of one month. The biochemical parameters like blood glucose, serum lipid profile, the level of thiobarbituric acid reactive substances, enzymic (CAT, SOD, GPX) and nonenzymic (Vitamin C, Vitamin E, GSH) antioxidants were analysed using standard methods before and after the treatment period. The data obtained were subjected to analysis of variance (ANOVA) Result: Supplementation of the tuber to Type 2 diabetics showed a substantial decrease in blood glucose, total, LDL, VLDL cholesterol, triglyceride level and a significant (p<0.05) improvement in HDL cholesterol level. The Analysis of Variance clearly indicated that the treatment adopted for Group III subjects (Diabetics + C. borivillianum) was on par with Group IV subjects (Diabetics + glibenclamide). Improved antioxidant status was observed in the controls supplemented with C. borivillianum. Before the treatment diabetics exhibited very low levels of enzymic and nonenzymic antioxidants, but after treatment, these levels significantly increased in the diabetics administered with the tuber of Chlorophytum borivillianum. It was found to be much higher than that of the diabetics taking glibenclamide. Conclusion: To conclude, the tuber of C. borivillianum has excellent antioxidant potential and is antihyperglycemic and antihyperlipidemic. The antidiabetic effect produced by the tuber of C. borivillianum is more effective than the drug glibenclamide.
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PA03.15. Study on relation of Prakriti with academic stress in school going children
Atika Madhukar, O Nisha Kumari, Abhimanyu Kumar
January 2013, 32(6):84-84
Purpose: Fast pace of life, highly competitive school environment and parental pressure brought child life cumbersome and full of stress and anxiety. These lead to maladjustment in different spheres of life such as home, social, health, emotion and educational problems. Testing or examination can produce anxiety in students, and can lower student's self‑esteem, and increase their fear of failure. School‑related stress is the most prevalent, untreated cause of academic failure in schools. Prevalence rates of anxiety disorders in community samples, based on clinical interviews vary between 21‑29%. In this present study a relation between prakriti and academic stress was assessed for the proper management of academic stress in this competitive world. Method: Children, aged between 10‑16 years, for the present study were screened out from OPD of National Institute of Ayurveda, Jaipur and from various schools, situated in Jaipur by survey method. Result: Maximum numbers of patients with Academic stress belonged to vata‑pitta parkriti. Conclusion: Vata Prakriti predisposes the child to develop academic stress as compared to pitta and kapha prakriti and multiple approach includoa ing medhyadrug, shirodhara and prakriti based Ayurvedic counseling is very much effective to manage the condition of Academic stress.
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PA03.16. Role of herbal immunomodulators in Paediatric practice
I Nilesh Manohar, O Nisha Kumari, Abhimanyu Kumar
January 2013, 32(6):85-85
Purpose: Immunomodulators are the herbal drugs that augments or diminishes the immune response. Immunity is of prime concern to paediatric population as they fall prey to most of the infections due to the lowered immunity. This study is directed towards identification and establishment of such herbal drugs that can be use in day‑to‑day paediatric practice for boosting the immune potential of children. Method: There is wide range of herbal immunomodulators in Ayurveda. Especially for pediatric age group Amalki, Guduchi, Yashtimadhu, Tulasi, Haridra, Pippali, Shatavari, Ashwagandha, Rason, and Nimba are evident as an important herbal immunomodulators. Efforts are made to justify immunomodulatory potential of above drugs on the basis of extensive search of Ayurvedic literature and the available research article related to these herbal drugs. Result: Study shows that herbal drugs have therapeutic strategy that enhances the overall resistance to the disease causing agent than directly neutralizing the agent itself. Conclusion: Immunomodulation with Ayurvedic Herbal Drugs can be safely and effectively prescribed for promotion of health and overall resistance against the diseases in paediatric population.
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PA02.01. Critical analysis of Doshik karma in twak
Nagaraj Kamath, Pratibha Kulkarni
January 2013, 32(6):46-46
Purpose: In normalcy, dosha will be performing their own functions in their own specific site. In the verses related to the sthana of dosha we can easily find out that in all the 3 verses skin or the structure related to skin as the sthana of one or other dosha. By mentioning the various sthanas of the each dosha, different function performed by individual dosha in different sites has been emphasised. So there is the need to understand the hidden physiological aspects of dosha related to skin. Method: The bruhat trayi were scrutinised regarding the references for the sthana and karma of the dosha. Later, physiologico anatomical aspects of the skin were studied from modern physiology books. Later, supportive correlation was done between ayurvedic and modern views to build valid and reliable hypothesis regarding the physiology of the dosha in skin. Result: Among the list of vata stana the word 'sparshanendriyam' is used, which attributes all the sensory function to vata dosha. Among the list of sthanas of pitta dosha the word 'sparshanam' is used, by this acharyas intended to highlight the function of pigmentation. 'Meda' is considered as the sthana of kapha. This can be considered as the adipose tissue of skin/below skin, can also considered as the secretion from the sweat glands since sweda is mala of meda. Sweat maintains water balance which refers to kleda vidrathi function of sweda. In various conditions the cholinergic sympathetic nerves get stimulated and sweat is excreted out which is ksepta bahi malanam function of vata dosha. Conclusion: With respect to skin doshic physiology can be concluded as vata will be carrying out sensory functions and excretion of sweat, pitta will be carrying out function of pigmentation, kapha will carrying out the function of production of sweating which in turn maintains the water balance.
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PA02.02. A comprehensive review of "Vaidya Vinoda"manuscript with reference to formulations and pharmaceutical procedures
Ramakant Vyas
January 2013, 32(6):47-47
Purpose: Ayurvedic literature is very vast & most of them are the form of manuscripts. Manuscripts of samhitas & commentaries give a proper view of clinical methods & stages of development in ayurvedic pharmaceutics. Sharangadhara Samhita is known as a landmark of Bhaishjya kalpna. Therefore it has been included in laghutrayi & many commentaries have been written on this book and also translated in many regional languages. "Vaidya Vinod" is also a translation of Sharangadhara Samhita into Marwari language written by Ramchandrayati, with his own contribution, in 17th century, the period of King Aurangzeb. This manuscript was neither studied nor translated till now. Objectives of the study •Report new formulations. •Report possible reason of change in S.O.P. • Report S.O.P. changes in formulations of Sharangadhara Samhita. •Contribution of "Vaidya Vinod" in completion of slokas. 2600 slokas are reported in Sharangadhara Samhita but only 2395 slokas are found in published books & manuscript of sharangdhar samhita. Method:
  1. Collection of all available copies of the manuscript.
  2. Translation of manuscript in Hindi.
  3. Comparative study of all chapters with Sharangadhara Samhita.
  1. 36 new formulations, not found in Sharangdhar samhita.
  2. 64 less formulations as compared to Sharangdhar samhita.
  3. 68 formulations have different S.O.P.
Conclusion: Manuscript has been written by a Jain saint in 17th century. It is written in Marwari language with the use of chhandas. Sharangdhar samhita has 12 chapters in madhyam khand but in this manuscript, there are 13 chapters in the same section of book. Study of manuscript suggests regionally popular formulations & different S.O.P. that help in preparing Ras Shastriya & herbal formulations. The present study was carried out with the help of two available manuscripts and one reported earlier copy was not found. Original copy may be helpful in 'sloka poorti' & 'patha bheda'.
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PA02.03. Pharmaceutical standardization of Ropya raj rasa
Sachin Agrawal, Rajendra Prassad
January 2013, 32(6):48-48
Purpose: New drug discovery is the need of the hour as we see considerable increase in the number and nature of diseases. Though Ayurveda, the ancient science of medicine, has number of unique formulations in its armory. These formulations in the Rasashastra texts which are said to be possessing very high therapeutic values but are not manufactured by any pharmaceutical industries due to lack of SOP and SMP regarding the pharmaceutical procedures. Ropya Raj Rasa is one such formulation which has ambiguity regarding its ingredients, pharmaceutical procedure and the final product. At the same time it has been mentioned highly effective in Bhagandara. Hence with an objective to find out answers to this ambiguity regarding pharmaceutical procedure of Ropya Raj Rasa. Method: The present study was conducted where in all available meanings for "Rasendra" and "Mlechhakshara" were considered and used for preparation. Totally six different combinations were formulated for "Rasendra" and "Mlechhakshara" meaning. At the end of the study, the optimum temperature required for the formulation, the accurate combination of "Rasendra" and "Mlechhakshara", the drugs to be taken in the name of "Rasendra" and "Mlechhakshara" were concluded as a part of pharmaceutical standardization. Result: Out of six combinations, one with the Hingula and Navasadara demonstrated the signs of completion as mentioned in the text "Bhramati Taravata on Dhamana". Conclusion: Samples containing Somala did not demonstrate the sign of completion. Thus it would be rational to conclude that with the reference Rasendra is Hingula and Mlechhakshara is Navasadara.
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PA02.04. A comparative study of loha rasayana prepared by ayaskriti and modified method w.s.r. disintegration of Iron.
P Anjali Baijnath, Moharpal Meena
January 2013, 32(6):49-49
Purpose: Loha Rasayana one of the important Rasayana referred in Charaka Samhita is known for its Rasayana effect. This approach to the formulations was so rational and perfect that it fulfils the expectation of the scientific masses even also in terms of today's Nanoparticle theory. This technique got improvised with time and experience and is now used to make the Bhasmas. Purpose of present study was to scrutinize the validation of the process referred in Charaka Samhita to render the metal therapeutically suitable to the body and procedure by which the Bhasmas are prepared and to analyse them on ancient and modern parameters. Method: •Loha Rasayana was prepared as per Cha.Chi. 13/1523 by using Ayaskriti. •Samples were collected and subjected to analysis at different interval of time to trace the ongoing changes in the medicine. •Loha Rasayana was analytically compared with the Bhasma and also with a sample of Loha Rasayana prepared by using Bhasma on ancient and modern parameters. •The samples were subjected to XRD, ICPAES, SEM, Organoleptic tests, Physico chemical, Assay of Iron Content, Particle size, TLC and Alcohol Content. Result: Analytical Tests: LRA LRB Particle Size(200) 68.0% 88%, Particle Size (325) 4% 7%, TLC (Rf) 0.25 0.024, Alcohol content %2.12% 4.28%, ICP AES (Fe) % 66.45% 51.32%, Total Iron Content %36.40 43.50, Ferrous Content %7.23 7.09, Ferric Content % 29.49 37.91, XRD Hematite & Magnetite Hematite Conclusion: Submersion of Iron in Acidic media for 12 months reduced Iron to 68% and 88% of the Ayaskriti and Bhasma to pass through 200 mess size. Alcohol content of the samples was well within the limit (2.12% and 4.28) and Ferrous content were found to increase in both samples to 7.23% & 7.09%.
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PA03.21. To evaluate the effect of Vaman, Kanak Bindu Aristha & Kusthakalanal Taila on Psoriasis
Saurabh Singh Hada, Mahender Singh Meena
January 2013, 32(6):90-90
Purpose: It Psoriasis is one the most dreadful dermatological condition affecting up to 2.5% of the world's & approximately 0.8% Indian population. is a common, chronic and non- infectious skin disease characterized by well defined slightly raised, dry erythematous macules with silvery scales and typical extensor distribution affecting any sex. In Ayurveda all dermatological conditions are grouped under broad term Kustha. Ayurveda has its own systemic approach plan to treat diseases. In the case of treating Kustha, Acharyas has specifically emphasized on Shaodhan Chikitsa ,Shamana because of its repeated relapse. So in this present study we selected Vamana procedures of Panchkarma which are like Biopurification procedures of body and drug kanakbinduarishta, kushtakalanal Taila. Method: Selection of Cases: The study was conducted on 30 clinically diagnosed and confirmed cases of Psoriasis randomly divided into 2 groups. Group A was administered vaman, kanak bindu arishta and local app. of kustha kalanal oil. Group B was administered kanak bindu arishta and local app. of kustha kalanal oil. The duration of the trial was for 3 Months. The drugs used were Kanak bindu arishta, Kushta kalanal taila and Oil-as per requirement The criteria for assessment was Pasi score,Kandu,Mandala rupa Result: In the evaluation the results were highly significant in Group A and all criteria were PASI (t = 9.63, p <0.001), Kandu (t = 9.28, p <0.001), Daha (t = 6.50, p <0.001). In the evaluation the results were highly significant in Group B and all criteria were PASI (t = 9.63, p <0.001), Kandu (t = 9.28, p <0.001), Daha (t = 6.50, p <0.001). Conclusion: Thus finally we can conclude that Vaman followed by administration of kanakbindu arishta and local application of kushta kalanal oil is effective in management of Psoriasis as it is safe, cost effective & free from any side effects. It also prevents the relapse considerably.
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PA03.22. Importance of Agni Chikitsa in the management of Grahani Disease w.s.r to Lavanabhaskara Churna
Mangala Wange
January 2013, 32(6):91-91
Purpose: To see the effect of Lavanbhaskar churna as a agnideepanchikitsa in Grahniroga Method: Diagnosed Patient of Grahaniroga was selected from the OPD of the Vidarbha Ayurved Mahavidyalaya, Hospital,Amravati after screening them as per Ayurvedic criteria for Grahaniroga. Selected 15 patients were received 3 to 6 gram Lavanbhaskarachurna with water. For two times a day for 2 month. Result: It is observed that relief in various symptoms of Grahni roga was found, for example relief in Aruchi was 67.64%,in the Agnimandya it was 69.23%, in Trushna it was66.66%, in Chardi 70.965 relief and in Adhman 58.82% relief while in case of Asamyak mal pravrutti it was 58.62% relief was observed. Conclusion: In the above study showed that nine patient out of fifteen got markedly symptomatic improvement while three got moderately effect, while two patients got mild relief in symptoms, one patient not relief this indicates that lavanbhaskar churna (Agnideepan chikitsa) is highly effective in Grahni roga.
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PA03.23. To Evaluate the efficacy of "Vajikar Kalp" in Male sexual dysfunction
Amol Khedkar
January 2013, 32(6):92-92
Purpose: To evaluate the efficacy of an aphrodisiac preparation in male sexual dysfunction. Method: The Vajikar Kalp was administered in 30 patients at the dosage of 2 gms twice a day with luke warm cow's milk. The combination was made of 1.Asparagus Racemosa - 500 mg, 2 .Tribulus Terrestris - 500 mg, 3. Mucuna Pruriens - 500 mg, 4. Withania Somnifera - 500 mg.Patients were observed on days 0, 15, 30, 60 and 90. International Index of Erectile Function was used to assess the improvement. Other subjective parameters were also checked before and after the treatment. Result: The Clinical Study was conducted for making the data more reliable and authentic. In a 90 day Study Kalp offered significant improvement in Erectile Dysfunction, Libido, and Ejaculation & Orgasm. Kalp offered statistically significant increase in Testosterone level. Vajikar Kalp offered significant increase in sexual desire, intercourse frequency, intercourse satisfaction and orgasmic function. Conclusion: The study demonstrated that the Vaijkar Kalp made of herbs was effective in improving male sexual dysfunction.
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PA03.24. Assessment of Ayurvedic treatment on Aphonia as a complication of Thyroidectomy.
Shruti Phatak
January 2013, 32(6):93-93
Purpose: To assess efficacy of Ayurvedic treatment on Aphonia resulted as complication of Thyroidectomy. Method: A female patient of age 32 was reffered by Surgery department for the treatment of Aphonia resulted as complication of Thyroidectomy Result: After giving Ayurvedic treatment for 15 days patient recovered significantly recovering her voice , after that treatment of about 2 months she completely recovered and regained her voice back. Conclusion: Ayurvedic treatment might be an efficient modality to treat Aphonia as a complication of Thyroidectomy.
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PA04.01. Role of prakruti in vocational guidance
Hemangini Waghulade
January 2013, 32(6):94-94
Purpose: If you want to work at something that is fulfilling & inspiring, you should tailor your career to your personal interests. So it becomes essential for an individual to choose profession according to his passion & liking. Here prakruti concept will help us out. The aim of study is:- To study the concept of prakruti in context of vocational guidance.To establish the interrelationship between prakruti & vocational guidance. Method: The concept of prakruti in context of vocational guidance is studied in Ayurvedic texts such as Charak Samhita, Sushruta Samhita , Ashtanga Sangraha, Ashtanga Hridaya, Harit Samhita & the available commentaries on it . Modern texts & related websites have also been searched for studying vocational guidance & the interrelationship between prakruti & vocational guidance is established. By knowing the prakruti of a particular person, we can get an appropriate idea about his likings or the things he is comfortable with. So, we can guide the person in choosing appropriate profession which will be according to his liking or passion & also he will have the ability to become successful in that particular profession. For e.g. Vata prakruti people can be good general practitioners as they are active & love talking. Pitta can be good surgeons, CMOs or neurosurgeons as they are courageous. Kapha people can better work as Ayurved consultants, psychiatrists as it requires great patience. Result: Vocational guidance is closely related with prakriti. One can advise a particular job profile according to one's prakruti. Conclusion: The conceptual study of prakruti is helpful in various vocational guidance centers & also in assigning a particular designation to an employee based on his ability.
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PA03.18. Clinical efficacy of mahaushadhikwath in amvaat using scientific parameters
Namrata Koli
January 2013, 32(6):87-87
  1. To study lakshnik upshaya in aamvata 2) Correlate efficacy of kwath using clinical parameter 3) To study usage of this kwath w.s.r shatkriyakaal of aamvaat.
Method: Mahaushadhi kwath 40 ml twice a day included guduchi and sunth referred from yogratnakar all men and women from age group of 18- 60 yrs will be included textual lakshanas mentioned will be considered pathologically ESR will be monitered , xray of involved joined before and after will be studied scientific parameters like woman scale for pain, stiffness and daily activity will be studied. vas scale for pain, ring method for swelling and lakshanik upashay gradation method will be implemented sclerosis, gout, tb joints, fracture, shiphylitc joint,etc will be excluded all data will be statistically proven and well represented. Result: Statistically significant results were seen in swelling , stiffness and generalised symptoms ESR was lowered in most cases thereby inlammation was seen reduced pain was not statistically sifnificant but improved statistically when given with eranda. Conclusion: Mahaushadhi kwath proves useful to breakdowm bheda avastha of aamvaata.
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PA03.19. Clinical study on the effect of Moorchita Tila Taila Shamana Sneha and Navaka Guggulu in Hyperlipidemia ‑ A comparative study
JM Prajwal Kumar, Sidram Guled, KS Shantharam, Gajanana Hegde
January 2013, 32(6):88-88
Purpose: Hyperlipidemia is a disorder which is identified as a potential risk factor for multitudes of diseases like cardiovascular diseases, metabolic syndrome and even hypertension. Hyperlipidemia is term used to denote raised serum levels of cholesterol or triglycerides or both. Though, there is no precise terminology for Hyperlipidemia mentioned in the Ayurvedic classics, A detailed study of Hyperlipidemia reveals its similarity to Asthayi Medo Dhatu Vriddhi on the basis of its Pathophysiology. Method: For Group A Moorchita Tila Taila 15ml twice daily as Shamana Sneha with Ushna jala for 30 days. For Group B Navaka Guggulu in Tablet form 500mg, 1 tab thrice daily for 30 days. Result: Both the groups A and B showed reduction in serum Total Cholesterol, Triglycerides, LDL‑C and VLDL‑C and Group A showed slight increase in HDL levels. Conclusion: Shamananga snehapana can be safely carried out in patients of Hyperlipidemia. Comparing both the groups, Group A treated with Moorchita Tila Taila Shamana Sneha showed better results in reducing serum lipid values than Group B treated with Navaka Guggulu
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PA03.20. Algorithm for ayurvedic management of vatarakta
Ram Manohar
January 2013, 32(6):89-89
Purpose: Ayurvedic treatment is individualised for each patient depending on a number of factors like constitution, type of disease and stage of disease. An attempt is being made to outline the treatment algorithm for Ayurvedic management of Vatarakta. Method: The algorithm has been developed by a careful study of the classical Ayurvedic texts of Caraka, Susruta, Vagbhata, Cakradatta and others. In addition, the clinical records of a few practitioners who have treated Vatarakta have also been examined to develop the treatment algorithm. Result: The classical texts of Ayurveda have discussed about the treatment of Vatarakta from the point of view of the type and stage of the disease. It is possible to create a sketch of the algorithm on the basis of textual inputs. However the texts do not explicitly provide the logistics for individualisation on the basis of constitution, digestive capacity, condition of alimentary tract and so on. These need to be derived from general principles. It has been found that actual practices by physicians do not fully correspond to the algorithm mentioned in the texts. Conclusion: It is possible to develop treatment algorithms for management of specific diseases by careful study of the classical texts of Ayurveda. These algorithms can be modified appropriately and fine tuned on the basis of inputs from clinical practice of experienced physicians in the field.
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